In vivo magnetic resonance vascular imaging using laser-polarized gas microbubbles
Patent 6051208 Issued on April 18, 2000. Estimated Expiration Date: April 8, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Nuclear magnetic resonance (NMR) images of a human or animal subject's vascular system are enhanced by injecting a liquid comprised of a biocompatible liquid carrier and a dispersion of hyperpolarized gas microbubbles into the subject, followed by generating an image by NMR representing a spatial distribution of the hyperpolarized gas microbubbles injected into the human or animal subject's vascular system. Preferably, the hyperpolarized gas is Helium-3 and/or Xenon-129. The microbubbles most preferably have a mean diameter of less than about 35 μm.
Other References
In vivo magnetic resonance vascular imaging using laser-polarized 3 He microbubbles; Mark S. Chawla, et al; Proc. Natl. Acad. Sci. USA; vol. 95, pp. 10832-10835, Sep. 1998, Medical Sciences
Biological magnetic resonance imaging using laser-polarized 129 Xe; M.S. Albert, et al.; Department of Chemistry, State University of New York, Stony Brook, New York 11794-3400, USA; Department of Physics, Princeton University, Princeton, New Jersey 08544, USA; Letters of Nature, pp. 199-201 Jul. 1994
MR Imaging with Hyperpolarized 3 He Gas; Hunter Middleton, et al., MRM 33:271-275 (1995); Department of Physics, Princeton University, Princeton, NJ; Depts. Of Biomedical Engineering and Physics, Duke University, Durham, NC; pp. 271-275
In Vivo He-3 MR Images of Guinea Pig Lungs; Robert D. Black, et al., Technical Developments and Instrumentation; Center for in Vivo Microscopy, Duke University, pp. 867-870 (1996)
In Vivo MR Imaging and Spectroscopy Using Hyperpolarized 129 Xe; Mark E. Wagshul, et al.; MRM 36:183-191 (1996); Depts. Radiology and Chemistry
NMR of laser-polarized xenon in human blood (optical pumping/laser-polarized xenon); A. Bifone et al.; Proc. Natl. Acad. Sci. USA, vol. 93, pp. 12932-12936, Nov. 1996, Biophysics
In vivo NMR and MRI using injection delivery of laser-polarized xenon; B.M. Goodson et al.; Proc. Natl. Acad. Sci. USA, vol. 94, pp. 14725-14729, Dec. 1997, Medical Sciences
Brain MRI with Laser-Polarized 129 Xe; Scott D. Swanson et al.; MRM 38:695-698 (1997)
Solubility of inert gases in biological fluids and tissues: a review; P.K. Weathersby and L.D. Homer, Naval Medical Research Institute, Bethesda, MD 20014; pp. 277-296 (1980)
Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms; W. Happer, et al; Department of Physics, Princeton University, Princeton, NJ 08544 .COPYRGT. 1984 The American Physical Society; pp. 3092-3110 (1984)
Polarized, high-density, gaseous 3 He targets; T.E. Chupp et al; Physical Review C, vol. 36, No. 6, Dec. 1987, pp. 2244-2251
Nuclear relaxation of3 He in the presence of O2 ; B. Saam, et al., Physical Review A, vol. 52, No. 1, Jul. 1995; pp. 862-865
Myocardial Contrast Echocardiography: A Reproducible Technique of Myocardial Opacification for Identifying Regional Perfusion Deficits; Chuwa Tel, M.D., et al.; Dept. of Medicine, Univ. of California School of Medicine, Wadsworth Veterans Administration Medical Center and Cedars-Sinai Medical Center, Los Angeles, CA; pp. 585-593 (1983)
Dynamics of Magnetization in hyperpolarized Gas MRI of the Lung; C. Allan Johnson, et al.; MRM 38:66-71 (1997)
MR Microscopy of Lung Airways with Hyperpolarized 3 He; X. Josette Chen, et al; MRM 39:79-84 (1998)
Three-Dimensional Time-of-Flight Magnetic Resonance Angiography Using Spin Saturation; C.L. Dumoulin et al; General Electric Research and Development Center; MRM 11:35-46 (1989)
Mirobubble Dynamics Visualized in the Intact Capillary Circulation; StevenB. Feinstein, MD, et al.; JACC, vol. 4, No. 3, Sep. 1984, 595-600
Nuclear Magnetic Resonance Imaging of Airways in Humans with Use of Hyperpolarized 3 He; Peper Bachert, et al; MRM 36:192-196 (1996)
Contrast Echyocardiography; J.W. Winkelmann, et al.; University of Illinois at Chicago, Chicago, IL, pp. 507-515 (1994)
Principles and Practice of Nuclear Medicine; Paul J. Early et al.; Second Edition; pp. 376-420 (1995)
A Rapid-Gated Cine MRI Technique; Gary H. Glover et al.; Magnetic Resonance Annual 1988; pp. 299-33
April 8, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
