Method for identifying variations in polynucleotide sequences
March 28, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for amplifying nucleic acid sequences Detection of mutations in nucleic acids Multiplexed fluorescence detector system for capillary electrophoresis Method for testing for mutations in DNA from a patient sample Methods for coupled high temperatures reverse transcription and polymerase chain reactions Multiplex genomic DNA amplification for deletion detection High-throughput screening method for sequence or genetic alterations in nucleic acids using elution and sequencing of complementary oligonucleotides Consensus sequence of the human BRCA1 gene 17q-linked breast and ovarian cancer susceptibility gene Coding sequences of the human BRCA1 gene Patent #: 5750400 InventorsApplicationNo. 825487 filed on 03/28/1997US Classes:435/6, Involving nucleic acid435/91.2, Acellular exponential or geometric amplification (e.g., PCR, etc.)536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA536/24.33PrimersExaminersPrimary: Horlick, Kenneth R.Assistant: Taylor, Janell E. Attorney, Agent or FirmInternational ClassC12Q 001/68AbstractA step-wise integrated process for identifying sequence variations in polynucleotide sequences is disclosed. The identification process is composed of three stages, including allele specific hybridization assays of known sequence variations (Stage I), sequence variation locating assays (Stage II), and direct sequencing (Stage III). The methods can be used for efficient and accurate detection of mutations in any test gene sample.Other References
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