Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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US Patent 6043252 - Carboline derivatives
US Patent Issued on March 28, 2000
Estimated Patent Expiration Date:
September 16, 2018Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
September 16, 2018Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractCarboline derivatives of formula (I) ##STR1## are potent and selective inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase (cGMP-specific PDE) and have utility in a variety of therapeutic areas where such inhibition is thought to be beneficial, including the treatment of cardiovascular disorders and erectile dysfunction. | InventorAssigneeApplicationNo. 154052 filed on 09/16/1998US Classes:514/292, Plural ring nitrogens in the tricyclo ring system546/85The six-membered hetero ring shares ring members with the five-membered cyclo only (e.g., pyrido-indoles, etc.)Field of Search514/292, Plural ring nitrogens in the tricyclo ring system546/85The six-membered hetero ring shares ring members with the five-membered cyclo only (e.g., pyrido-indoles, etc.)ExaminersPrimary: Jones, Dwayne C.Assistant: Delacroix-Muirheid, C. Attorney, Agent or FirmUS Patent References4801587, Impotence ointmentIssued on: 01/31/1989 Inventor: Voss , et al.5770606, Dosage forms and method for ameliorating male erectile dysfunction Issued on: 06/23/1998 Inventor: El-Rashidy, et al.5874437Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses Issued on: 02/23/1999 Inventor: Garvey, et al. International ClassA61K 031/44 |
