...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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AbstractCarboline derivatives of formula (I) ##STR1## are potent and selective inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase (cGMP-specific PDE) and have utility in a variety of therapeutic areas where such inhibition is thought to be beneficial, including the treatment of cardiovascular disorders and erectile dysfunction. | InventorAssigneeApplicationNo. 154052 filed on 09/16/1998US Classes:514/292, Plural ring nitrogens in the tricyclo ring system546/85The six-membered hetero ring shares ring members with the five-membered cyclo only (e.g., pyrido-indoles, etc.)Field of Search514/292, Plural ring nitrogens in the tricyclo ring system546/85The six-membered hetero ring shares ring members with the five-membered cyclo only (e.g., pyrido-indoles, etc.)ExaminersPrimary: Jones, Dwayne C.Assistant: Delacroix-Muirheid, C. Attorney, Agent or FirmUS Patent References4801587, Impotence ointmentIssued on: 01/31/1989 Inventor: Voss , et al.5770606, Dosage forms and method for ameliorating male erectile dysfunction Issued on: 06/23/1998 Inventor: El-Rashidy, et al.5874437Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses Issued on: 02/23/1999 Inventor: Garvey, et al. International ClassA61K 031/44 |