Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
Patent 6043024 Issued on March 28, 2000. Estimated Expiration Date: 
April 18, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 18, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesUse of nuclear magnetic resonance to identify ligands to target biomolecules Use of nuclear magnetic resonance to identify ligands to target biomolecules Patent #: 5804390 InventorsApplicationNo. 844124 filed on 04/18/1997US Classes:435/4, MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP422/50, ANALYZER, STRUCTURED INDICATOR, OR MANIPULATIVE LABORATORY DEVICE422/62, Automatic analytical monitor and control of industrial process422/68.1, Means for analyzing liquid or solid sample422/69, Sorption testing422/82.01, Measuring electrical property435/5, Involving virus or bacteriophage435/6, Involving nucleic acid435/7.1, Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay435/286.1, Including condition or time responsive control means435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid435/289.1, Bioreactor435/810, PACKAGED DEVICE OR KIT436/501BIOSPECIFIC LIGAND BINDING ASSAYExaminersPrimary: Marschel, Ardin H.International ClassC12Q 001/68AbstractThe present invention provides a process for identifying compounds which bind to a specific target molecule. The process comprises the steps of: a) generating a first T2 - or diffusion-filtered proton spectrum of one or a mixture of chemical compounds; b) exposing one or a mixture of chemical compounds to the target molecule; c) generating a second T2 - or diffusion-filtered proton spectrum of one or a mixture of chemical compounds that has been exposed the target molecule in step (b); and d) comparing said first and second T2 - or diffusion-filtered proton spectra to determine differences between said first and said second spectra, the differences identifying the presence of one or more compounds that are ligands which have bound to the target molecule.Other References
Field of SearchInvolving virus or bacteriophageInvolving nucleic acid Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay PACKAGED DEVICE OR KIT MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP Including condition or time responsive control means Including measuring or testing Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid Bioreactor BIOSPECIFIC LIGAND BINDING ASSAY ANALYZER, STRUCTURED INDICATOR, OR MANIPULATIVE LABORATORY DEVICE Automatic analytical monitor and control of industrial process Means for analyzing liquid or solid sample Sorption testing Measuring electrical property |
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