Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
Patent 6040446 Issued on March 21, 2000. Estimated Expiration Date: 
July 31, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 31, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent Antiviral compounds 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative Patent #: 5856481 Inventors
ApplicationNo. 127380 filed on 07/31/1998US Classes:544/276, Nitrogen attached directly or indirectly to the purine ring system by nonionic bonding560/106, Ring in alcohol moiety560/254Aromatic alcohol moietyExaminersPrimary: Berch, Mark L.Attorney, Agent or FirmForeign Patent References
International ClassC07D 473/18AbstractProcess and novel intermediates for preparing the L-mono-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts. The present process and intermediates provide for reduced impurities in the mono-valine ester end-product and lower overall production costs. The process involves the condensation of a silylated guanine compound with a substituted glycerol derivative and esterification of this product with an L-valine derivative. These mono-valine products are of value as antiviral agents with improved absorption.Other References
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