Patent References 3545439 Polymeric diffusion matrix containing estradiol diacetate Easily removable tampon Channeled vaginal insert and method for treating urogenital disorders Intravaginal drug delivery devices for the administration of 17ଲ-oestradiol precursors Patent #: 5855906 InventorAssigneeApplicationNo. 102302 filed on 06/22/1998US Classes:424/433Depot, pellet, matrix, or suppositoryExaminersPrimary: Azpuru, CarlosAttorney, Agent or FirmInternational ClassA61F 013/02Foreign Application Priority Data1997-06-24 GBAbstractThe invention provides an intravaginal drug delivery system having a first intravaginal part comprising at least one active agent in a polymer matrix, said first part being provided in association with a second part comprising a removable polymer membrane arranged to absorb excess active agent. Use of a polymer membrane in this way serves to substantially reduce the initial high burst of active from the intravaginal part following administration. It also reduces the levels of release of active during the first few weeks of use. Also provided is an intravaginal drug delivery device comprising at least one active agent dispersed in a polymer matrix, wherein the concentration of active agent at the outer surface of the device at the time of use is not substantially higher than the concentration of the active agent in the remainder of the device.Field of SearchDepot, pellet, matrix, or suppository | |