Ceramic fusion implants and compositions
October 20, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesHydroxylapatite ceramic Bone morphogenetic protein process Biodegradable porous ceramic delivery system for bone morphogenetic protein Place holder, in particular for a vertebra body Osteoinductive factors Surgical prosthetic implant facilitating vertebral interbody fusion V-thread fusion cage and method of fusing a bone joint DNA sequences encoding osteoinductive products Threaded spinal implant Surgical method and apparatus for fusing adjacent bone structures InventorAssigneeApplicationNo. 955003 filed on 10/20/1997US Classes:423/305, Metal or ammonium containing423/311, Orthophosphate424/423, Surgical implant or material523/115, Composition suitable for use as tooth or bone replacement, restorative, or implant524/415Atom other than P, O, H, or a metalExaminersPrimary: Yu, MickeyAssistant: Nguyen, Tan T. Attorney, Agent or FirmForeign Patent References
International ClassesA61F 002/28A61F 002/44 AbstractBone graft substitute compositions are provided for promoting new bone growth and arthrodesis. The compositions include a carrier for controlled delivery of osteoinductive factors. In one embodiment, the carriers include a biphasic calcium phosphate ceramic having between about 2-40% hydroxyapatite and about 98-60% tricalcium phosphate by volume, and a calcium/phosphorous ratio of between about 1.50 to about 1.60. The invention also includes osteoinductive compositions including the carriers and an effective amount of a bone morphogenetic protein dispersed within the ceramic. The composition has a weight ratio of protein to ceramic of no more than about 1:200. In a specific embodiment, the weight ratio of protein to ceramic is between about 1:200 and about 1:2000. Spinal implants (10) are also provided which include a body (11) having a wall (12) sized for engagement within a space (S) between adjacent vertebrae (V) to maintain the space (S) and a confining matrix (13) for confining new bone growth to the body (11). The matrix (13) includes a biphasic calcium phosphate ceramic which degrades at a rate to provide calcium and phosphate for the new bone growth without reduced density of bone adjacent the space and an effective amount of a substantially pure osteogenic factor bound to the ceramic.Other References
Field of SearchInternal fixation meansSpinal positioner or stabilizer Metal or ammonium containing Hydrogen containing Orthophosphate (e.g., calcium hydroxyapatite) Orthophosphate Implantable permanent prosthesis (i.e., artificial body member) (e.g., pacemaker, lens, cornea, glaucoma shunt, heart valve, muscle, spinal disc, breast, internal organ) For mineralized body part (e.g., bone, tooth, crown, hip) Inorganic oxygen-containing compound containing layer formed (e.g., hydroxyapatite, ceramic, glass) Composition suitable for use as tissue or body member replacement, restorative, or implant Composition which anchors by ingrowth of surrounding tissue Composition suitable for use as tooth or bone replacement, restorative, or implant Cement or filling composition Atom other than P, O, H, or a metal Implant or insert Surgical implant or material Membrane or diffusion barrier Diffusion barrier is matrix |
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