Patent ReferencesMethod for the assay of classes of antigen-specific antibodies Immunoassay for antigens Sensor having piezoelectric crystal for microgravimetric immunoassays Analytical device and method utilizing a piezoelectric crystal biosensor Signal amplification in an assay employing a piezoelectric oscillator Apparatus and method for detecting small changes in attached mass of piezoelectric devices used as sensors Electronic component having a plate-shaped element Enzymatically amplified piezoelectric specific binding assay Method and apparatus for measuring the product of an antigen-antibody reaction Resonator device adapted for suppression of fluctuation in resonant resistance, and method of producing same Patent #: 5828159 InventorsAssigneeApplicationNo. 938115 filed on 09/26/1997US Classes:435/6, Involving nucleic acid310/311, Piezoelectric elements and devices310/312, Adding or subtracting mass310/313R, Surface acoustic wave devices310/340, Encapsulated or coated310/348, With mounting or support means422/82.01, Measuring electrical property435/7.21, Animal cell435/7.32, Bacteria or actinomycetales435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/524, Carrier is inorganic436/525, Metal or metal coated436/527Glass or silicaExaminersPrimary: Chin, Christopher L.Attorney, Agent or FirmInternational ClassG01N 033/543AbstractA piezoelectric sensor and assembly for measuring chemical, biochemical and physical measurands is disclosed. The piezoelectric sensor comprises a piezoelectric material, preferably a crystal, a common metal layer attached to the top surface of the piezoelectric crystal, and a pair of independent resonators placed in close proximity on the piezoelectric crystal such that an efficacious portion of acoustic energy couples between the resonators. The first independent resonator serves as an input port through which an input signal is converted into mechanical energy within the sensor and the second independent resonator serves an output port through which a filtered replica of the input signal is detected as an electrical signal. Both a time delay and an attenuation at a given frequency between the input signal and the filtered replica may be measured as a sensor output. The sensor may be integrated into an assembly with a series feedback oscillator and a radio frequency amplifier to process the desired sensor output. In the preferred embodiment of the invention, a selective film is disposed upon the grounded metal layer of the sensor and the resonators are encapsulated to isolate them from the measuring environment. In an alternative embodiment of the invention, more than two resonators are used in order to increase the resolution of the sensor.Field of SearchPiezoelectric elements and devicesSurface acoustic wave devices Adding or subtracting mass Encapsulated or coated With mounting or support means Measuring electrical property Involving nucleic acid Animal cell Bacteria or actinomycetales Including measuring or testing Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS Carrier is inorganic Metal or metal coated Glass or silica |
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