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US Patent 6033852 - Monolithic piezoelectric sensor (MPS) for sensing chemical, biochemical and physical measurands

US Patent Issued on March 7, 2000
Estimated Patent Expiration Date: Icon_subject September 26, 2017Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A piezoelectric sensor and assembly for measuring chemical, biochemical and physical measurands is disclosed. The piezoelectric sensor comprises a piezoelectric material, preferably a crystal, a common metal layer attached to the top surface of the piezoelectric crystal, and a pair of independent resonators placed in close proximity on the piezoelectric crystal such that an efficacious portion of acoustic energy couples between the resonators. The first independent resonator serves as an input port through which an input signal is converted into mechanical energy within the sensor and the second independent resonator serves an output port through which a filtered replica of the input signal is detected as an electrical signal. Both a time delay and an attenuation at a given frequency between the input signal and the filtered replica may be measured as a sensor output. The sensor may be integrated into an assembly with a series feedback oscillator and a radio frequency amplifier to process the desired sensor output. In the preferred embodiment of the invention, a selective film is disposed upon the grounded metal layer of the sensor and the resonators are encapsulated to isolate them from the measuring environment. In an alternative embodiment of the invention, more than two resonators are used in order to increase the resolution of the sensor.

Inventors

Assignee

Application

No. 938115 filed on 09/26/1997

US Classes:

435/6, Involving nucleic acid310/311, Piezoelectric elements and devices310/312, Adding or subtracting mass310/313R, Surface acoustic wave devices310/340, Encapsulated or coated310/348, With mounting or support means422/82.01, Measuring electrical property435/7.21, Animal cell435/7.32, Bacteria or actinomycetales435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/524, Carrier is inorganic436/525, Metal or metal coated436/527Glass or silica

Field of Search

310/311, Piezoelectric elements and devices310/313R, Surface acoustic wave devices310/312, Adding or subtracting mass310/340, Encapsulated or coated310/348, With mounting or support means422/82.01, Measuring electrical property435/6, Involving nucleic acid435/7.21, Animal cell435/7.32, Bacteria or actinomycetales435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/524, Carrier is inorganic436/525, Metal or metal coated436/527Glass or silica

Examiners

Primary: Chin, Christopher L.

Attorney, Agent or Firm

US Patent References

4236893, Method for the assay of classes of antigen-specific antibodies
Issued on: 12/02/1980
Inventor: Rice
4242096, Immunoassay for antigens
Issued on: 12/30/1980
Inventor: Oliveira ,   et al.
4735906, Sensor having piezoelectric crystal for microgravimetric immunoassays
Issued on: 04/05/1988
Inventor: Bastiaans
4789804, Analytical device and method utilizing a piezoelectric crystal biosensor
Issued on: 12/06/1988
Inventor: Karube ,   et al.
4847193, Signal amplification in an assay employing a piezoelectric oscillator
Issued on: 07/11/1989
Inventor: Richards ,   et al.
4905701, Apparatus and method for detecting small changes in attached mass of piezoelectric devices used as sensors
Issued on: 03/06/1990
Inventor: Cornelius
4920296, Electronic component having a plate-shaped element
Issued on: 04/24/1990
Inventor: Takahashi, et al.
4999284, Enzymatically amplified piezoelectric specific binding assay
Issued on: 03/12/1991
Inventor: Ward, et al.
5001053, Method and apparatus for measuring the product of an antigen-antibody reaction
Issued on: 03/19/1991
Inventor: Takahashi, et al.
5828159Resonator device adapted for suppression of fluctuation in resonant resistance, and method of producing same
Issued on: 10/27/1998
Inventor: Miyagawa, et al.

International Class

G01N 033/543

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