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AbstractA piezoelectric sensor and assembly for measuring chemical, biochemical and physical measurands is disclosed. The piezoelectric sensor comprises a piezoelectric material, preferably a crystal, a common metal layer attached to the top surface of the piezoelectric crystal, and a pair of independent resonators placed in close proximity on the piezoelectric crystal such that an efficacious portion of acoustic energy couples between the resonators. The first independent resonator serves as an input port through which an input signal is converted into mechanical energy within the sensor and the second independent resonator serves an output port through which a filtered replica of the input signal is detected as an electrical signal. Both a time delay and an attenuation at a given frequency between the input signal and the filtered replica may be measured as a sensor output. The sensor may be integrated into an assembly with a series feedback oscillator and a radio frequency amplifier to process the desired sensor output. In the preferred embodiment of the invention, a selective film is disposed upon the grounded metal layer of the sensor and the resonators are encapsulated to isolate them from the measuring environment. In an alternative embodiment of the invention, more than two resonators are used in order to increase the resolution of the sensor. | InventorsAssigneeApplicationNo. 938115 filed on 09/26/1997US Classes:435/6, Involving nucleic acid310/311, Piezoelectric elements and devices310/312, Adding or subtracting mass310/313R, Surface acoustic wave devices310/340, Encapsulated or coated310/348, With mounting or support means422/82.01, Measuring electrical property435/7.21, Animal cell435/7.32, Bacteria or actinomycetales435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/524, Carrier is inorganic436/525, Metal or metal coated436/527Glass or silicaField of Search310/311, Piezoelectric elements and devices310/313R, Surface acoustic wave devices310/312, Adding or subtracting mass310/340, Encapsulated or coated310/348, With mounting or support means422/82.01, Measuring electrical property435/6, Involving nucleic acid435/7.21, Animal cell435/7.32, Bacteria or actinomycetales435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/524, Carrier is inorganic436/525, Metal or metal coated436/527Glass or silicaExaminersPrimary: Chin, Christopher L.Attorney, Agent or FirmUS Patent References4236893, Method for the assay of classes of antigen-specific antibodiesIssued on: 12/02/1980 Inventor: Rice4242096, Immunoassay for antigens Issued on: 12/30/1980 Inventor: Oliveira , et al.4735906, Sensor having piezoelectric crystal for microgravimetric immunoassays Issued on: 04/05/1988 Inventor: Bastiaans4789804, Analytical device and method utilizing a piezoelectric crystal biosensor Issued on: 12/06/1988 Inventor: Karube , et al.4847193, Signal amplification in an assay employing a piezoelectric oscillator Issued on: 07/11/1989 Inventor: Richards , et al.4905701, Apparatus and method for detecting small changes in attached mass of piezoelectric devices used as sensors Issued on: 03/06/1990 Inventor: Cornelius4920296, Electronic component having a plate-shaped element Issued on: 04/24/1990 Inventor: Takahashi, et al.4999284, Enzymatically amplified piezoelectric specific binding assay Issued on: 03/12/1991 Inventor: Ward, et al.5001053, Method and apparatus for measuring the product of an antigen-antibody reaction Issued on: 03/19/1991 Inventor: Takahashi, et al.5828159Resonator device adapted for suppression of fluctuation in resonant resistance, and method of producing same Issued on: 10/27/1998 Inventor: Miyagawa, et al. International ClassG01N 033/543 |