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US Patent 6017963 - Formulation for intranasal administration

US Patent Issued on January 25, 2000
Estimated Patent Expiration Date: Icon_subject November 14, 2015Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A dosage form for intranasal and/or inhalation administration of an analgesic having low opioid receptor binding activity to a warm blooded animal, that includes a pharmaceutically effective amount of the analgesic. A preferred analgesic is tramadol, a tramadol and/or a pharmaceutically acceptable salt, metabolite or derivative thereof. Methods of making and using the formulation according to the invention are also provided.

Other References

  • Chemical Abstracts AN: 108: 82103, Chrnbasik et al, "Analgesic use by Inhalation" corresponds to DE 3602370 A1, Aug. 6, 1986. Remington's Pharmaceutical Sciences, p. 1451, 198

Inventors

Assignee

Application

No. 557279 filed on 11/14/1995

US Classes:

514/646Benzene ring containing

Field of Search

514/646Benzene ring containing

Examiners

Primary: MacMillan, Keith D.

Attorney, Agent or Firm

US Patent References

3652589, 4440777, Use of eucalyptol for enhancing skin permeation of bio-affecting agents
Issued on: 04/03/1984
Inventor: Zupan
4464378, Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
Issued on: 08/07/1984
Inventor: Hussain
4624965, Novel method of administering anti-nausea and anti-emetic pharmaceutical agents and novel dosage forms containing same
Issued on: 11/25/1986
Inventor: Wenig
4729997, Novel method of administering meclizine type pharmaceutical agents and novel dosage forms containing same
Issued on: 03/08/1988
Inventor: Wenig
4749700, Novel methods of administering antihistamines, antinausea and antiemetic pharmaceutical agents and novel dosage forms containing same
Issued on: 06/07/1988
Inventor: Wenig
4778810, Nasal delivery of caffeine
Issued on: 10/18/1988
Inventor: Wenig ,   et al.
4880813, Method of treatment for allergic rhinitis
Issued on: 11/14/1989
Inventor: Frost
4973596, Method of administering a narcotic analgesic and dosage forms therefor
Issued on: 11/27/1990
Inventor: Cohen
5066648, Pyroglutamic acid esters used as dermal penetration enhancers for drugs
Issued on: 11/19/1991
Inventor: Alexander, et al.
5204119, External preparation comprising calcium silicate
Issued on: 04/20/1993
Inventor: Shiobara, et al.
5223541, Tramadol N-oxide material, enantiomers and compositions thereof, and their use
Issued on: 06/29/1993
Inventor: Maryanoff, et al.
5336691, Composition comprising a tramadol material and acetaminophen and its use
Issued on: 08/09/1994
Inventor: Raffa, et al.
5446070, 5451408, Pain management with liposome-encapsulated analgesic drugs
Issued on: 09/19/1995
Inventor: Mezei, et al.
5468744Composition comprising a tramadol material and any of codeine, oxycodone or hydrocodone and their use
Issued on: 11/21/1995
Inventor: Raffa, et al.

Foreign Patent References

  • WO9315737 WO 08/21/1993
  • WO9404133 WO 03/21/1994
  • WO9410987 WO 05/21/1994
  • WO9422445 WO 10/21/1994

International Class

A61K 031/135

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