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Combinations for diabetes

Patent 6011049 Issued on January 4, 2000. Estimated Expiration Date: Icon_subject November 9, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventor

Application

No. 189132 filed on 11/09/1998

US Classes:

514/369, Chalcogen bonded directly to ring carbon of the thiazole ring514/342, Ring sulfur in the additional hetero ring514/593, Sulfur is part of a substituent which contains additional nitrogen514/635, Biguanides (i.e., N=C(-N)-N(N-)C=N)514/866DIABETES

Examiners

Primary: Jordan, Kimberly

Attorney, Agent or Firm

Foreign Patent References

  • 0749751 EP. 12/13/1996
  • 0753298 EP. 01/13/1997
  • 9609823 WO. 04/13/1996

International Classes

A61K 031/44
A61K 031/425
A61K 031/175
A61K 031/155

Abstract

Combinations of a glitazone antidiabetic agent and a biguanide antidiabetic agent, and optionally a sulfonylurea antidiabetic agent, are useful for treating diabetes mellitus and improving glycemic control.

Other References

  • PCT International Search Report, PCT/US97/21996
  • Oakes, et al., Diabetes, vol. 13:1203, 1994, A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat
  • Hulin, et al, Current Pharmaceutical Design 2:85-102, 1996, The Glitazone Family of Antidiabetic Agents
  • Groop, M.D., Diabetes Care, 15:737-754, 1992, Sulfonylureas in NIDDM
  • Nakano, et al., CS-045, Clinical Evaluation of a New Oral Hypoglycemic Drug, CS-045, on Daily Profile of Blood Glucose in Patients with Non-Insulin Dependent Diabetes Mellitus (1993)
  • Company News On-Call, 1-3, 1997 Rezulin.RTM. (troglitazone) Receives FDA Marketing Clearance for use as Either Initial or Combination Therapy for Type 2 Diabetes
  • Spencer, et al., Drugs, vol. 54:89-101, 1997, Troglitazone
  • Yamasaki, et al., The Tokohu Journal of Experimental Medicine, vol. 183:173-183, 1997, Pioglitazone (AD-4833) Ameliorates Insulin Resistance in Patients with NIDDM
  • Iwamoto, et al., Diabetic Medicine, vol. 13:365-370, 1996, Effect of Combination Therapy of Troglitazone and Sulphonylureas in Patients with Type 2 Diabetes Who Were Poorly Controlled by Sulphonylurea Alon
  • Bressler & Johnson., Drugs& Aging, vol. 9:418-437, 1996, Oral Antidiabetic Drug Use in the Elderly
  • Okaka, et al., Chemical Abstracts, vol. 126, No. 20, 1997, Abstract No. 258925, Antidiabetic Effects of Pioglitzone HCL Alone or in Combination with Insulin or Sylfonylurea in Diabetic Animals
  • De Souza, et al., Diabetes, vol. 44:984-991, 1995, Insulin Secretory Defect in Zucker fa/fa Ratsis Improved by Ameliorating Insulin Resistanc
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