Patent 6011049 Issued on January 4, 2000. Estimated Expiration Date: November 9, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/369, Chalcogen bonded directly to ring carbon of the thiazole ring514/342, Ring sulfur in the additional hetero ring514/593, Sulfur is part of a substituent which contains additional nitrogen514/635, Biguanides (i.e., N=C(-N)-N(N-)C=N)514/866DIABETES
Combinations of a glitazone antidiabetic agent and a biguanide antidiabetic agent, and optionally a sulfonylurea antidiabetic agent, are useful for treating diabetes mellitus and improving glycemic control.
Other References
PCT International Search Report, PCT/US97/21996
Oakes, et al., Diabetes, vol. 13:1203, 1994, A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat
Hulin, et al, Current Pharmaceutical Design 2:85-102, 1996, The Glitazone Family of Antidiabetic Agents
Groop, M.D., Diabetes Care, 15:737-754, 1992, Sulfonylureas in NIDDM
Nakano, et al., CS-045, Clinical Evaluation of a New Oral Hypoglycemic Drug, CS-045, on Daily Profile of Blood Glucose in Patients with Non-Insulin Dependent Diabetes Mellitus (1993)
Company News On-Call, 1-3, 1997 Rezulin.RTM. (troglitazone) Receives FDA Marketing Clearance for use as Either Initial or Combination Therapy for Type 2 Diabetes
Spencer, et al., Drugs, vol. 54:89-101, 1997, Troglitazone
Yamasaki, et al., The Tokohu Journal of Experimental Medicine, vol. 183:173-183, 1997, Pioglitazone (AD-4833) Ameliorates Insulin Resistance in Patients with NIDDM
Iwamoto, et al., Diabetic Medicine, vol. 13:365-370, 1996, Effect of Combination Therapy of Troglitazone and Sulphonylureas in Patients with Type 2 Diabetes Who Were Poorly Controlled by Sulphonylurea Alon
Bressler & Johnson., Drugs& Aging, vol. 9:418-437, 1996, Oral Antidiabetic Drug Use in the Elderly
Okaka, et al., Chemical Abstracts, vol. 126, No. 20, 1997, Abstract No. 258925, Antidiabetic Effects of Pioglitzone HCL Alone or in Combination with Insulin or Sylfonylurea in Diabetic Animals
De Souza, et al., Diabetes, vol. 44:984-991, 1995, Insulin Secretory Defect in Zucker fa/fa Ratsis Improved by Ameliorating Insulin Resistanc