Lipophilic-polycationic delivery systems
December 21, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesNovel functionallized liposomes and a process for production thereof Methods of treating Parkinson's disease using melanin Microreservoir liposome composition and method Synthesis and utilization of therapeutic agents for the treatment of lysosomal storage diseases Phospholipids containing omega-3-fatty acids Deposition of materials to surfaces using zwitterionic carrier particles Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents Patent #: 5604198 InventorsAssigneeApplicationNo. 487693 filed on 06/07/1995US Classes:514/549, Z radical contains carbon to carbon unsaturation514/552, Z contains an unbroken chain of at least seven carbon atoms bonded directly to the C(=O) group514/558, Higher fatty acid or salt thereof514/560Carbon to carbon unsaturationExaminersPrimary: Smith, Lynette R. F.Assistant: Lee, Datquan Attorney, Agent or FirmInternational ClassesA01N 037/06A01N 037/02 A61K 031/22 A61K 031/23 AbstractThe present invention describes site-specific biomolecular complexes comprising a therapeutic, prophylactic and diagnostic agent, called also biologically active molecule and an omega-3 fatty acid and derivatives thereof. The complexes are further covalently bonded with cationic carriers and permeabilizer peptides for delivery across the blood-brain barrier and with targeting moieties for uptake by target brain cells. Said complexes are particularly useful for delivery of a biologically active agent to the glial tissue of the brain as well as to the cortical, cholinergic and adrenergic neurons. The preferred therapeutic complexes or conjugates comprise an omega-3 fatty acid such as alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid and derivatives thereof.Other References
Field of SearchZ radical contains carbon to carbon unsaturationHeavy metal containing (e.g., hemoglobin, etc.) Z contains an unbroken chain of at least seven carbon atoms bonded directly to the C(=O) group Glycoprotein (carbohydrate containing) Higher fatty acid or salt thereof 25 or more peptide repeating units in known peptide chain structure Carbon to carbon unsaturation Produced by or extracted from animal tissue Waxes, fatty acids, etc. (e.g., liposome, etc.) Polymer from ethylenic monomers only Errodable, resorbable, or dissolving Liposomes Stabilized enzymes or enzymes complexed with nonenzyme (e.g., liposomes, etc.) Multienzyme complexes or mixtures of enzymes 11 to 14 amino acid residues in defined sequence CARRIER-BOUND OR IMMOBILIZED ENZYME OR MICROBIAL CELL; CARRIER-BOUND OR IMMOBILIZED CELL; PREPARATION THEREOF Carrier is synthetic polymer Attached to the carrier via a bridging agent Enzyme or microbial cell is entrapped within the carrier (e.g., gel, hollow fibre) | |
