U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems

Patent 6004515 Issued on December 21, 1999. Estimated Expiration Date: Icon_subject October 27, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Sample dilution
Patent #: 4036062
Issued on: 07/19/1977
Inventor: Cruzan

Sample dilution
Patent #: 4070913
Issued on: 01/31/1978
Inventor: Roof

Silicon semiconductor wafer for analyzing micronic biological samples
Patent #: 4908112
Issued on: 03/13/1990
Inventor: Pace

Capillary flow device
Patent #: 4963498
Issued on: 10/16/1990
Inventor: Hillman, et al.

Method and device for moving molecules by the application of a plurality of electrical fields
Patent #: 5126022
Issued on: 06/30/1992
Inventor: Soane, et al.

Capillary flow device
Patent #: 5140161
Issued on: 08/18/1992
Inventor: Hillman, et al.

Device for processing biological specimens for analysis of nucleic acids
Patent #: 5188963
Issued on: 02/23/1993
Inventor: Stapleton

Fluid handling in mesoscale analytical devices
Patent #: 5304487
Issued on: 04/19/1994
Inventor: Wilding, et al.

Methods for controlling electroosmotic flow in coated capillary electrophoresis columns
Patent #: 5391274
Issued on: 02/21/1995
Inventor: Shieh

Analysis based on flow restriction
Patent #: 5486335
Issued on: 01/23/1996
Inventor: Wilding, et al.

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Inventors

Assignee

Application

No. 179336 filed on 10/27/1998

US Classes:

422/100, Pipette or other volumetric fluid transfer means73/863, SAMPLER, SAMPLE HANDLING, ETC.204/600, Electrophoretic or electro-osmotic apparatus422/58, In holder or container having special form422/68.1, Means for analyzing liquid or solid sample436/52, With a continuously flowing sample or carrier stream436/179, Dilution436/180Volumetric liquid transfer

Examiners

Primary: McKane, Elizabeth
Assistant: Moazzam, Fariborz

Attorney, Agent or Firm

Foreign Patent References

  • WO 9405414 WO. 03/13/1994
  • WO 9604547 WO. 02/13/1996
  • WO 9702357 WO. 01/13/1997

International Classes

B01L 003/00
B01L 011/00

Abstract

The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perform a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.

Other References

  • Bao, J. et al., "Ultramicro enzyme assays in capillary electrophoretic system," J. Chrom. 608:217-224 (1992)
  • Dasgupta, P.K. et al., "Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis," Anal. Chem. 66:1792-1798(1994)
  • Harrison, D.J. et al., "Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip," Science 261:895-897 (1993)
  • Jacobson, S.C. et al., "Precolumn Reactions with Electrohoretic Analysis Integrated on a Microchip," Anal. Chem. 66:4127-4132 (1994)
  • Jacobson, S.C. et al., "Fused Quartz Substrates for Microchip Electrophoresis," Anal. Chem. 67:2059-2063 (1995)
  • Linhares, M.C. et al., "Use of an On-Column Fracture in Capillary Zone Electrophoresis for Sample Introduction," Anal. Chem. 63:2076-2078 (1991)
  • Manz, A. et al., "Miniaturized Total Chemical Analysis Systems: a Novel Concept for Chemical Sensing," Sensors and Actuators B1:244-248 (1990)
  • Manz, A. et al., "Micromachining of monocrystalline silicon and glass for chemical analysis systems," Trends in Anal. Chem. 10(5):144-149 (1991)
  • Manz, A. et al., "Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems," J. Micromech. Microeng. 4:257-265 (1994)
  • Ramsey, J.M. et al., "Microfabricated chemical measurement systems," Nature Med. 1:1093-1096 (1995)
  • Seiler, K. et al., "Planar Glass Chips for Capillary Electrophoresis: Repetitive Sample Injection, Quantitation, and Separation Efficiency," Anal. Chem.65:1481-1488(1993)
  • Seiler, K. et al., "Electroosmotic Pumping and Valveless Control of Fluid Flow Within a Manifold of Capillaries on a Glass Chip," Anal. Chem. 66:3485-3491 (1994)
  • Woolley, A.T. et al., "Ultra-high-speed DNA fragment separation using microfabricated capillary array electrophoresis chips," Proc. Natl. Acad. Sci. U.S.A.. 91:11348-11352 (1994
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