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Nasopharynx administration of mupirocin for prophylactic treatment of recurrent otitis media

Patent 6001870 Issued on December 14, 1999. Estimated Expiration Date: Icon_subject September 30, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventor: Hunter ,   et al.

Pharmaceutical composition
Patent #: 4879287
Issued on: 11/07/1989
Inventor: Orr, et al.

Crystalline calcium pseudomonate
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Polymorphs of crystalline mupirocin Patent #: 5594026
Issued on: 01/14/1997
Inventor: Greenway, et al.

Inventor

Assignee

Application

No. 940730 filed on 09/30/1997

US Classes:

514/460, Chalcogen bonded directly to ring carbon of the hetero ring424/434, Mucosal (e.g., nasal, etc.)514/956Aural or otic (i.e., ear)

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

Foreign Patent References

  • 0 069 423 EP 01/13/1983
  • 0 095 897 EP 12/13/1983
  • 0 167 856 EP 01/13/1986
  • 231621 EP. 08/13/1987
  • 251434 EP. 01/13/1988
  • WO 84/02076 WO 06/13/1984
  • WO9510999 WO. 04/13/1995
  • WO 95/10999 WO 04/13/1995
  • WO9814189 WO. 04/13/1998

International Classes

A61K 031/35
A61K 009/06
A61K 009/10
A61K 009/107

Foreign Application Priority Data

1997-08-09 GB

Abstract

Mupirocin or a salt or ester thereof may be used to treat recurrent sinusitis and recurrent otitis, in particular with novel spray or cream formulations adapted for administration to the nasopharynx.

Other References

  • Bertino et al Am. J. Health-Syst. Pharm. 54(19): 2185-2191, 1997
  • Naka Gawa et al Kagaku Ryohono Ryoiki 12(9): 1659-1667, 1995
  • Anon: J. Am Soc. Nephrol. 7(11): 2403-2408, 1996
  • Nakagawa et al Kagaku Ryohono Ryoiki 12(7): 1293-1296, 1996
  • Finlay et al Antimicrob. Agents Chemotherapy 41(5): 1137-1139, 1997
  • Nakamichi et al Yakurito Chiryo 24(1): 85-92, 1996
  • Raz, Raul et al Arch Intern. Med. 156(10): 1109-1112, 1996
  • Bloom et al Am. J. Kidney Dis. 27(5): 687-694, 1996
  • Nsouli, et al., "Nasal Topical Antimicrobial Agent, Mupirocin-(Bactroban), in the Prophylaxis of Repeated Paranasal Sinusitis (RPS): A Double Blind Placebo Control Study", Annals. of Allergy, Asthma and Immunology, vol. 76(1): pp. 117, (1996)
  • "Mupirocin", Merk Index, 11th edn., pp. 993, (1989
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