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Processes for spray drying aqueous suspensions of hydrophobic drugs and compositions thereof

Patent 6001336 Issued on December 14, 1999. Estimated Expiration Date: Icon_subject December 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Spray-dried vitamin powders using hydrophobic silica
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Process for the preparation of activated pharmaceutical compositions
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Sustained release oral suspensions
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Issued on: 03/12/1991
Inventor: Kogan, et al.

Process for spray drying riboflavin to produce a granulate product having low binder content
Patent #: 5000888
Issued on: 03/19/1991
Inventor: Kilbride, Jr., et al.

Process for the preparation of an antioxydant extract of spices
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Inventor: Aeschbach, et al.

Inhalation pharmaceuticals
Patent #: 5260306
Issued on: 11/09/1993
Inventor: Boardman, et al.

Aerosol carriers
Patent #: 5376386
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Process for preparing therapeutic compositions containing nanoparticles
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Issued on: 04/23/1996
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Inventor

Assignee

Application

No. 999095 filed on 12/29/1997

US Classes:

424/46, Powder or dust containing424/45, Organic pressurized fluid424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/499, Contains proteins or derivative or polysaccharides or derivative514/938, Oil-water type514/958FOR SMOKING OR INHALING

Examiners

Primary: Page, Thurman K.
Assistant: Channavajjala, Lakshmi

Attorney, Agent or Firm

Foreign Patent References

  • 0611567 EP 08/13/1994
  • WO 88/07870 WO 10/13/1988
  • WO 91/16882 WO 11/13/1991
  • WO 94/07514 WO 04/13/1994
  • WO 95/24183 WO 09/13/1995
  • WO 95/23613 WO 09/13/1995
  • WO 96/09814 WO 04/13/1996
  • WO 97/36574 WO 10/13/1997

International Class

A61L 009/14

Abstract

Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions or suspensions of the components and spray drying them simultaneously in a spray drier. The hydrophilic component is dissolved in an aqueous solution and the hydrophobic component suspended therein. The method provides dry powders having relatively uniform characteristics.

Other References

  • Bloch et al., "Dispersions of hydrochlorothiazide and chlorthalidone in pentaerythritol" Pharm. Acta Helv. (1983) 58(1):14-22. An English abstract is also enclosed herewith
  • Dialog.RTM. Abstract of German Patent Publication No. DE 2209477. Sep. 6, 1973, One page total
  • Dialog.RTM. Abstract of French Patent Publication No. FR. 2594693, Apr. 1987, One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 4036233. Feb. 6, 1992, One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 7101881. Apr. 18, 1995, One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 7101883. Apr. 18, 1995, One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 7101884. Apr. 19, 1995, One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 7101882. Apr. 18, 1995, One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 7242568. Apr. 19, 1995, One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 8067666. Mar. 12, 1996, One page total
  • Mumenthaler et al. "Feasibility study on spray-drying protein pharmaceuticals: Recombinant human growth hormone and tissue-type plasminogen activator" Pharm. Res. (1994) 11(1):12-2
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