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Method for preparing biphasic multilamellar lipid vesicles

Patent 5993851 Issued on November 30, 1999. Estimated Expiration Date: Icon_subject March 13, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
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Multiphase liposomal drug delivery system
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Paucilamellar lipid vesicles
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Issued on: 03/27/1990
Inventor: Wallach

Stable plurilamellar vesicles
Patent #: 5030453
Issued on: 07/09/1991
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Patent #: 5169637
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Issued on: 08/10/1993
Inventor: Wallach

More ...

Inventor

Assignee

Application

No. 042097 filed on 03/13/1998

US Classes:

424/450, Liposomes264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)264/4.3, With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)264/4.32, Microcapsule wall containing two or more layers264/4.6, Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.)424/1.21, Molecular bilayer structure (e.g., vesicle, liposome)424/9.321, Liposome424/9.51, Liposome containing424/85.7, Alpha or leukocyte424/417Coated particulate form (e.g., liposome, etc.)

Examiners

Primary: Kishore, Gollamudi S.

Attorney, Agent or Firm

Foreign Patent References

  • 1143656 CA. 03/13/1983
  • 2018825 CA. 06/13/1990
  • 1280975 CA. 03/13/1991
  • 2024804 CA. 03/13/1991
  • 2018825 CA. 12/13/1991
  • 0130577 EP. 01/13/1985
  • 0292403 EP. 11/13/1988
  • 90/12565 WO. 11/13/1990
  • 91/01719 WO. 02/13/1991
  • 92/06676 WO. 04/13/1992
  • 92/19243 WO. 11/13/1992
  • 93/00894 WO. 01/13/1993

International Class

A61K 009/127

Abstract

A biphasic multilamellar lipid vesicle comprising a plurality of spaced apart lipid bilayers that include a liposome-forming component and optionally a biologically active agent entrapped within the lipid bilayers. The lipid vesicle also comprises peripheral aqueous solution compartments formed between the lipid bilayers and a central lipophilic core compartment substantially at the center of the multilamellar lipid vesicle.

Other References

  • Uekama, K. et al., "Improved Transdermal Delivery of Prostaglandin E1 Through Hairless Mouse Skin: Combined Use of Carboxymethyl-ethyl-ଲ-Cyclodextrin and Penetration Enhancers," Communications. 119-121 (1991)
  • Watkinson, A.C. et al., "Aspects of the Transdermal Delivery of Prostaglandins," International Journal of Pharmaceutics. 74 229-236 (1991)
  • Adam C. Watkinson et al., "Aspect of the Transdermal Delivery of Prostaglandins": International Journal of Pharmaceutics, 74 (1991); pp. 229-236
  • Kaneto Uekama et al., "Improved Transdermal Delivery of Prostaglandin E1 through Hairless Mouse Skin: Combined Use of Carboxymethyl-ethyl-ଲ-Cyclodextrin and Penetration Enhances"; Communications (1991): pp. 119-12
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