Polymeric bioadhesive emulsions and suspensions and methods of treatment
August 15, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesAqueous gel, usable in cosmetics, based on hyaluronic acid and deoxyribonucleic acid, and a preparation process Solubilizing, thickening and emulsifying cosmetic composition and process for preparation of same Isopropyl alcohol gel composition and process for preparing same Cosmetic composition in the form of an aqueous gel Cosmetic or pharmaceutical composition in the form of a rigid gel, particularly for containing inclusions therein Patent #: 5635171 InventorAssigneeApplicationNo. 914338 filed on 08/15/1997US Classes:424/78.02, TOPICAL BODY PREPARATION CONTAINING SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)424/78.18, Polymer derived from ethylenic monomers only424/78.29, Nitrogen heterocycle424/430, Vaginal, urethral, uterine424/433, Depot, pellet, matrix, or suppository424/434, Mucosal (e.g., nasal, etc.)424/435, Mouth424/436Anal, rectal (e.g., suppositories, etc.)ExaminersPrimary: Kulkosky, Peter F.International ClassesA61K 047/32A61K 009/02 AbstractBioadhesive/mucoadhesive composition in a suspension or emulsion form that delivers drugs to the target tissue in a sustained manner is formulated. A composition, method of manufacture and its application in treatment of mammalian tissue are disclosed. The composition includes a bioadhesive/mucoadhesive polymer in an emulsion or suspension form along with a treating agent. The treating agent could be as simple as water as in the case of mucoadhesive moisturizing agent. The bioadhesive/mucoadhesive polymer is a water dispersible high molecular weight crosslinked polyacrylic acid copolymer with free carboxylic acid groups further crosslinked with a combination mono, di and polyvalent metal ions, cationic polymers and surfactants. Type of metal ion and their concentration can be adjusted to get the desired bio/mucoadhesive properties along with several physical properties that are important to the formulation of dosage forms. The viscosity of the formulation can be reduced substantially by crosslinking with metal ions or by incorporating anions or cations in 0.01 to 5% to get low viscosity product with higher polymer concentration, which is important in several dosage forms. The concentration of the polymer ranges from 0.05 to 20.0 percent depending on the crosslinking and the viscosity of the product. | |
