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Processes for spray drying solutions of hydrophobic drugs and compositions thereof

Patent 5985248 Issued on November 16, 1999. Estimated Expiration Date: Icon_subject December 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Spray-dried vitamin powders using hydrophobic silica
Patent #: 4486435
Issued on: 12/04/1984
Inventor: Schmidt ,   et al.

Process for the preparation of activated pharmaceutical compositions
Patent #: 4540602
Issued on: 09/10/1985
Inventor: Motoyama ,   et al.

Inhalation pharmaceuticals
Patent #: 4590206
Issued on: 05/20/1986
Inventor: Forrester ,   et al.

Pharmaceutical composition and its rectal use
Patent #: 4670419
Issued on: 06/02/1987
Inventor: Uda ,   et al.

Sustained release oral suspensions
Patent #: 4999189
Issued on: 03/12/1991
Inventor: Kogan, et al.

Process for spray drying riboflavin to produce a granulate product having low binder content
Patent #: 5000888
Issued on: 03/19/1991
Inventor: Kilbride, Jr., et al.

Process for the preparation of an antioxydant extract of spices
Patent #: 5026550
Issued on: 06/25/1991
Inventor: Aeschbach, et al.

Inhalation pharmaceuticals
Patent #: 5260306
Issued on: 11/09/1993
Inventor: Boardman, et al.

Aerosol carriers
Patent #: 5376386
Issued on: 12/27/1994
Inventor: Ganderton, et al.

Process for preparing therapeutic compositions containing nanoparticles
Patent #: 5510118
Issued on: 04/23/1996
Inventor: Bosch, et al.

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Inventors

Assignee

Application

No. 999104 filed on 12/29/1997

US Classes:

424/46, Powder or dust containing424/45, Organic pressurized fluid424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/499, Contains proteins or derivative or polysaccharides or derivative514/951, POWDERS, GRANULES OR PARTICLES OF SPECIFIED MESH OR PARTICLE SIZE514/958FOR SMOKING OR INHALING

Examiners

Primary: Page, Thurman K.
Assistant: Channavajjala, Lakshmi

Attorney, Agent or Firm

Foreign Patent References

  • 0611567 EP 08/13/1994
  • WO 88/07870 WO 10/13/1988
  • WO 91/16882 WO 11/13/1991
  • WO 94/07514 WO 04/13/1994
  • WO 95/24183 WO 09/13/1995
  • WO 95/23613 WO 09/13/1995
  • WO 96/09814 WO 04/13/1996
  • WO 97/36574 WO 10/13/1997

International Class

A61L 009/14

Abstract

Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions or suspensions of the components and spray drying them simultaneously in a spray drier. Both the hydrophobic and hydrophilic component are dissolved in a solvent system selected to have adequate solubility for both components. The method provides dry powders having relatively uniform characteristics.

Other References

  • Bloch et al., "Dispersions of hydrochlorothiazide and chlorthalidone in pentaerythritol" Pharm. Acta. Helv. (1983) 58(1) : 14-22. An English abstract is also enclosed herewith
  • Dialog.RTM. Abstract of German Patent Publication No. DE 2209477. Sep. 06, 1973 One page total
  • Dialog.RTM. Abstract of French Patent Publication No. FR. 2594693 Arp. 1987 One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 4036233. Feb. 06, 1992 One page total
  • Dialog.RTM. Abstract of Japanese Patent Publications No. JP 7101881. Apr. 18, 1995 One Page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 7101883. Apr. 18, 195 One Page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 7101884. Apr. 18, 1995 One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 7101882. Apr. 18, 1995 One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. JP 7242568. Sep. 19, 1995 One page total
  • Dialog.RTM. Abstract of Japanese Patent Publication No. 8067666. Mar. 12, 1996 One page total
  • Mumenthaler et al. "Feasibility study on spray-drying protein pharmaceuticals: Recombinant human growth hormone and tissue-type plasminogen activator" Pharm. Res. (1994) 11(1): 12-2
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