Synthesis of optically pure compounds useful as GARFT inhibitors and their intermediates
Patent 5981748 Issued on November 9, 1999. Estimated Expiration Date: July 2, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
544/48, Three or more ring hetero atoms in the bicyclo ring system549/70, Having -C(=X)-, wherein X is chalcogen, bonded directly to the hetero ring549/71, The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens549/72Nitrogen or chalcogen attached indirectly to the hetero ring by nonionic bonding
The invention relates to methods of making compounds of the formula VII ##STR1## and their enantiomers, where Ar is a substituted or unsubstituted five- or six-membered aromatic group and B is either an amino acid linked through the amino portion to form an amide or a C1 -C6 alcohol linked through the alcohol portion to form an ester. These compounds are advantageously employed as intermediates to prepare optically pure compounds that are active GARFT inhibitors. In one method, a compound of the formula ##STR2## is reacted with a compound of the formula ##STR3## where X is a halogen.
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July 2, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
