Benzofurans and benzopyrans as chronobiological agents

Patent 5981572 Issued on November 9, 1999. Estimated Expiration Date:

November 6, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventors

Application

No. 180441 filed on 11/06/1998

US Classes:

514/456, Bicyclo ring system having the hetero ring as one of the cyclos (e.g., chromones, etc.)514/469, Bicyclo ring system having the hetero ring as one of the cyclos549/396, Bicyclo ring system having the hetero ring as one of the cyclos549/462Bicyclo ring system having the hetero ring as one of the cyclos

Examiners

Primary: Stockton, Laura L.

Attorney, Agent or Firm

Nixon & Vanderhye

Foreign Patent References

0042299A EP. 12/13/1981
WO 92/17464 WO. 10/13/1992
WO 93/12754 WO. 07/13/1993

International Classes

A61K 031/34
A61K 031/35
C07D 311/04
C07D 307/79

Foreign Application Priority Data

1996-05-14 GB

Abstract

The invention thus provides compounds of Formula (I) ##STR1## wherein R1 and R2 which may be the same or different represent H, C1-6 alkyl or substituted alkyl or C3-7 cycloalkyl; or aryl;R3, and R4 which may be the same or different represent H, halogen, C1-6 alkyl; or substituted aryl;R5 is H or C1-6 alkyl;n is an integer 0, 1 or 2and m is an integer 1, 2, 3, or 4;the dotted line indicates the presence or absence of an additional bond; and pharmaceutically acceptable solvates (e.g. hydrates) thereof.

Other References

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