ApplicationNo. 973561 filed on 12/02/1997
US Classes:514/283, Ring nitrogen in the pentacyclo ring system is shared by five-membered cyclo and six-membered cyclo (e.g., vincamine, etc.)514/280, Pentacyclo ring system having the six-membered hetero ring as one of the cyclos546/48Three or more ring hetero atoms in the pentacyclo ring system
ExaminersPrimary: Shah, Mukund J.
Assistant: Kifle, Bruck
Attorney, Agent or Firm
Foreign Patent References
International ClassesC07D 491/14
Foreign Application Priority Data1995-06-21 GB
AbstractA camptothecin analog characterized in that the hydroxy lactone of the camptothecin is a ଲ-hydroxy lactone or the corresponding ଲ-hydroxyacid, resulting from the opening of said lactone, or a derivative of said ଲ-hydroxyacid, or a Pharmaceutically acceptable salt thereof, is disclosed. In particular, compounds of formulae (I) and (II) are disclosed. Methods for preparing the compounds of formulae (I) and (II), pharmaceutical compositions containing said containing said compounds, and their use, particularly as topoisomerase inhibitors and antitumoral drugs, are also disclosed.