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US Patent 5980882 - Drug-resin complexes stabilized by chelating agents

US Patent Issued on November 9, 1999
Estimated Patent Expiration Date: Icon_subject April 16, 2017Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The invention provides a pharmaceutical composition comprising a drug-resin complex and a chelating agent in which the composition is in the form of a solid or a gel. The invention also provides a method of making such a composition and a method for improving the stability of a pharmaceutical composition.

Other References

  • Packaging for Delsym.RTM. DM Controlled-Release Dextromethorphan Polystirex Suspension, Ciba Self Medication, Mississanga, Ontario, Jan. 31, 199

Inventor

Assignee

Application

No. 834359 filed on 04/16/1997

US Classes:

424/78.12, Adsorbate or treating agent contains nitrogen424/78.1, Ion exchange resin424/483Ion-exchange resins

Field of Search

424/78.1, Ion exchange resin424/78.11, Plural ion exchange resins424/78.12, Adsorbate or treating agent contains nitrogen424/78.13, Oxygen or sulfur heterocycle424/78.14, Nitrogen heterocycle424/78.15, Plural nitrogen heteroatoms or rings424/78.16, Amine containing aromatic group424/78.17, Aftertreated polymer (e.g., grafting, blocking, etc.)424/483Ion-exchange resins

Examiners

Primary: Kulkosky, Peter F.

Attorney, Agent or Firm

US Patent References

2697059, 2751325, 2990332, 3035984, 3070503, 3070508, 3100738, 3108044, 3143465, 3352801, 3499960, 3594470, 4152493, Process for eliminating metal ions from a metal ion-containing liquid with solid chelate resins
Issued on: 05/01/1979
Inventor: Yotsumoto ,   et al.
4172120, Cholestyramine compositions and method for treating biliary gastritis
Issued on: 10/23/1979
Inventor: Todd ,   et al.
4221778, Prolonged release pharmaceutical preparations
Issued on: 09/09/1980
Inventor: Raghunathan
4252790, Method for treating gastric ulcer-prone patients
Issued on: 02/24/1981
Inventor: Higuchi
4358546, Spherical porous cross-linked copolymers of chloromethylstyrene and divinylbenzene and the derivative thereof
Issued on: 11/09/1982
Inventor: Naomi ,   et al.
4374932, 5-ASA Drug delivery system
Issued on: 02/22/1983
Inventor: Pitzele ,   et al.
4423158, Ion adsorbent for metals having a coordination number greater than two
Issued on: 12/27/1983
Inventor: Porath
4436738, Stabilized estradiol cream composition
Issued on: 03/13/1984
Inventor: Bequette ,   et al.
4448774, Steroid formulation
Issued on: 05/15/1984
Inventor: Clemente ,   et al.
4459278, Composition and method of immobilizing emetics and method of treating human beings with emetics
Issued on: 07/10/1984
Inventor: Porter
4578268, Diethylcarbamazine resinate and styrylpyridinium resinate-diethylcarbamazine resinate edible anthelmintic tablets for companion animals
Issued on: 03/25/1986
Inventor: Quinlan
4593073, Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids
Issued on: 06/03/1986
Inventor: St-Pierre ,   et al.
4692462, Compositions and method of controlling transdermal penetration of topical and systemic agents
Issued on: 09/08/1987
Inventor: Banerjee
4762709, Liquid prolonged release pharmaceutical formulations containing ionic constituents
Issued on: 08/09/1988
Inventor: Sheumaker
4780322, Method of producing slow-release pharmaceutical forms
Issued on: 10/25/1988
Inventor: Martani ,   et al.
4788055, Resinate sustained release dextromethorphan composition
Issued on: 11/29/1988
Inventor: Fischer ,   et al.
4847077, Controlled release pharmaceutical preparations
Issued on: 07/11/1989
Inventor: Raghunathan
4859461, Coatable ion exchange resins
Issued on: 08/22/1989
Inventor: Chow ,   et al.
4859462, Polymer-treated ion exchange resins
Issued on: 08/22/1989
Inventor: Chow ,   et al.
4894239, Sustained-release preparation and production thereof
Issued on: 01/16/1990
Inventor: Nonomura, et al.
4973607, Cation exchange resins incorporating antioxidants
Issued on: 11/27/1990
Inventor: Stahlbush, et al.
4996047, Sustained release drug-resin complexes
Issued on: 02/26/1991
Inventor: Kelleher, et al.
4999189, Sustained release oral suspensions
Issued on: 03/12/1991
Inventor: Kogan, et al.
5032393, Drug adsorbates
Issued on: 07/16/1991
Inventor: Douglas, et al.
5071646, Pharmaceutical ion exchange resin composition
Issued on: 12/10/1991
Inventor: Malkowska, et al.
5108733, Stabilized Trinder reagent
Issued on: 04/28/1992
Inventor: Frontini, et al.
5141966, Metalchelating, hydrophilic polymer
Issued on: 08/25/1992
Inventor: Porath
5152986, Preparation and use of ion exchange resins loaded with quinolonecarboxylic acid derivatives
Issued on: 10/06/1992
Inventor: Lange, et al.
5177076, Aqueous folinate solution stable at refrigerator temperature, as well as process for its preparation
Issued on: 01/05/1993
Inventor: Nijkerk, et al.
5182102, Anti-glaucoma compositions
Issued on: 01/26/1993
Inventor: DeSantis, Jr., et al.
5186930, Sustained release oral suspensions
Issued on: 02/16/1993
Inventor: Kogan, et al.
5188825, Freeze-dried dosage forms and methods for preparing the same
Issued on: 02/23/1993
Inventor: Iles, et al.
5200473, Chelating resins and method for their use in the extraction of metal ions
Issued on: 04/06/1993
Inventor: Jeanneret-Gris
5217954, Formulations for stabilizing fibroblast growth factor
Issued on: 06/08/1993
Inventor: Foster, et al.
5288503, Cryogel oral pharmaceutical composition containing therapeutic agent
Issued on: 02/22/1994
Inventor: Wood, et al.
5334378, Pharmaceutical formulation in the form of aqueous suspension
Issued on: 08/02/1994
Inventor: Mitani, et al.
5338532, Starburst conjugates
Issued on: 08/16/1994
Inventor: Tomalia, et al.
5350584, Spheronization process using charged resins
Issued on: 09/27/1994
Inventor: McClelland, et al.
5368852, Prolonged-release liquid type of pharmaceutical preparation comprising drug-resin complex and benzoate preservative
Issued on: 11/29/1994
Inventor: Umemoto, et al.
5413782, Binding pharmaceuticals to ion exchange resins
Issued on: 05/09/1995
Inventor: Warchol, et al.
5453429, Crosslinked anion exchange particles and method for producing the particles
Issued on: 09/26/1995
Inventor: Bliem, et al.
5540918, Use of certain anionic surfactants to enhance antimicrobial effectiveness of ophthalmic compositions
Issued on: 07/30/1996
Inventor: Castillo, et al.
5575993Ionene polymers containing biologically-active anions
Issued on: 11/19/1996
Inventor: Ward, et al.

Foreign Patent References

  • 4640351 JP 11/19/1971

International Classes

A61K 047/32
A61K 009/30

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