Water soluble paclitaxel prodrugs
March 11, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDerivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof Covalently-linked complexes and methods for enhanced cytotoxicity and imaging Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon Polymer-bound paclitaxel derivatives Monoclonal antibodies to prostate cells Polymer-bound paclitaxel derivatives Use of taxol in the treatment of rheumatoid arthritis Directed biodistribution of radiolabelled biotin using carbohydrate polymers High molecular weight polymer-based prodrugs Controlled local delivery of chemotherapeutic agents for treating solid tumors InventorsApplicationNo. 815104 filed on 03/11/1997US Classes:514/449, Oxygen containing hetero ring424/1.65, In an organic compound424/9.36, Transition, actinide, or lanthanide metal containing549/510, The hetero ring is four-membered549/511Sulfur or halogen attached directly or indirectly to the hetero ring by nonionic bondingExaminersPrimary: Dees, Jose G.Assistant: Hartley, Michael G. Attorney, Agent or FirmForeign Patent References
International ClassesA01N 043/02C07D 305/00 A61K 051/04 A61B 005/055 AbstractDisclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.Field of SearchIn an organic compoundTransition, actinide, or lanthanide metal containing Polyamino-polycarbonyl moiety attached to or complexed with the metal RADIOACTIVE METAL CONTAINING (At. No. 43, 61 or 84+; or radioactive isotope of another metal) Actinide series metal (At. No. 89+) Containing -C(=X)-, wherein X is chalcogen (e.g., carbonyl containing, etc.) The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens Technetium containing (At. No. 43; Tc) RARE EARTH METAL CONTAINING (At. No. 21, 39, 57-60 or 62-71) Containing -C(=X)X-, wherein the X's are the same or diverse chalcogens Oxygen containing hetero ring Hetero ring in the polycyclo ring system The hetero ring is four-membered Sulfur or halogen attached directly or indirectly to the hetero ring by nonionic bonding FROM PROTEIN OR BIOLOGICALLY ACTIVE POLYPEPTIDE REACTANT |
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