Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
Patent 5976858 Issued on November 2, 1999. Estimated Expiration Date: August 23, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
435/219, Proteinase435/184, Enzyme inactivation by chemical treatment514/18, 3 or 4 peptide repeating units in known peptide chain514/192 peptide repeating units in known peptide chain
Irreversible cysteine protease inhibitors based upon an alkene bond being conjugated to an electron withdrawing group are disclosed. The inhibitor structure also provides a targeting peptide which is specific for different cysteine proteases. The method of making the inhibitors, and methods of using the inhibitors to inhibit cysteine proteases and for therapy are disclosed.
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August 23, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
