Processes for spray drying hydrophobic drugs in organic solvent suspensions

Patent 5976574 Issued on November 2, 1999. Estimated Expiration Date:

December 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

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Inventor

Gordon, Marc S.

Assignee

Inhale Therapeutic Systems

Application

No. 999100 filed on 12/29/1997

US Classes:

424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/45, Organic pressurized fluid424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/470Where particles are granulated

Examiners

Primary: Page, Thurman K.
Assistant: Benston, William E. Jr.

Attorney, Agent or Firm

Townsend and Townsend and Crew LLP

Foreign Patent References

0611567 EP 08/13/1994
WO 88/07870 WO 10/13/1988
WO 91/16882 WO 11/13/1991
WO 94/07514 WO 04/13/1994
WO 95/24183 WO 09/13/1995
WO 95/23613 WO 09/13/1995
96/09814 WO 04/13/1996
WO 96/09814 WO 04/13/1996
97/36574 WO 10/13/1997

International Class

A61K 009/14

Abstract

Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions or suspensions of the components and spray drying them simultaneously in a spray drier. The hydrophobic component may be dissolved in an organic solvent and the hydrophilic component suspended therein. The method provides dry powders having relatively uniform characteristics.

Other References

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