Aqueous creatine solution and process of producing a stable, bioavailable aqueous creatine solution
Patent 5973005 Issued on October 26, 1999. Estimated Expiration Date: 
February 26, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 26, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod for restoring functionality in muscle tissue Creatine beverage and producing process thereof Method for reduction of serum blood lipids or lipoprotein fraction Amine acid salt compounds and process for the production thereof Patent #: 5686588 InventorsAssigneeApplicationNo. 031290 filed on 02/26/1998US Classes:514/565, N-N or N=C(-N)-N containing (e.g., hydrazines, hydrazones, or quanidines, etc.)562/560Ureido, hydrazino, or nitrogen double bonded directly to carbonExaminersPrimary: Reamer, James H.Attorney, Agent or FirmForeign Patent References
International ClassA61K 031/195AbstractA stable aqueous solution of creatine acid sulfate provides a source of creatine to an animal when taken orally. The aqueous solution of creatine acid sulfate (after neutralization and buffering) has a pH of about 7.2 to about 7.8 and is stable for at least six months at room temperature. The creatine acid sulfate is produced by adding creatine monohydrate to a sulfuric acid solution in a stoichiometric amount to result in creatine acid sulfate having a pH initially of 2.0-3.0. The resulting creatine acid sulfate is diluted with water and neutralized to raise the pH and avoid the formation of creatinine. The resulting creatine acid sulfate solution preferably contains a buffering and neutralizing agent such as tribasic potassium phosphate which forms mono- and dibasic potassium phosphates by interaction with the hydrogen ions liberated from the acid sulfate. The aqueous solution can be combined with a sweetener, electrolyte and carbohydrate source to produce a stable drink for providing a source of creatine to an animal in need thereof. An effective amount of glycerol is preferably added to enhance absorption of the creatine through the intestinal wall into the bloodstream and eventually to the needy skeletal muscles.Other References
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