Pharmaceutical preparation containing metformin and a process for producing it

Patent 5955106 Issued on September 21, 1999. Estimated Expiration Date:

March 14, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Controlled release pharmaceutical composition
Patent #: 4834985
Issued on: 05/30/1989
Inventor: Elger , et al.

Sustained-release formulations Patent #: 5055306
Issued on: 10/08/1991
Inventor: Barry, et al.

Inventors

Application

No. 793753 filed on 03/14/1997

US Classes:

424/464, Tablets, lozenges, or pills424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/480, Cellulose or derivative424/489Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)

Examiners

Primary: Page, Thurman K.
Assistant: Benston, William E. Jr.

International Class

A61K 009/20

Foreign Application Priority Data

1994-09-14 DE

Abstract

The present invention concerns pharmaceutical compositions containing metformin as an active substance and a hydrocolloid-forming agent as a retardant and optionally standard pharmaceutical auxiliary substances, the residual moisture content in the pharmaceutical composition being 0.5-3% by weight. The invention also concerns a process for producing pharmaceutical compositions containing metformin as an active substance and a hydrocolloid-forming agent as a retardant and optionally standard pharmaceutical auxiliary substances characterized in that the active substance and retarding agent or a portion thereof are granulated with an aqueous solvent which can optionally contain a binder and where appropriate the other portion of the retardant or other standard pharmaceutical auxiliaries are admixed with the granulate which is then dried until the residual moisture content is reduced to 0.5-3% by weight.