Conjugates useful in the treatment of prostate cancer
October 14, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesComplexes of DNA and esters derived from daunorubicine, their preparation and use Derivatives of doxorubicine, their preparation and use Vinblastin-23-oyl amino acid derivatives for use as antitumor agents Water-soluble acylated derivatives of peptides or amino acids, their preparation and their use Water soluble macromolecular prodrugs, their preparation and their use as antitumor and antiparasite medicines New conjugates of vinblastine and its derivatives, process for preparing them and pharmaceutical compositions containing them Conjugates of vinblastine, a process for their preparation and their use in therapy Conjugates of a vinca derivative carrying a detergent chain in the C-3 position Interfacial condensation of bioactive compounds and the site-specific compounds and conjugates thereof Covalently-linked complexes and methods for enhanced cytotoxicity and imaging InventorsAssigneeApplicationNo. 950805 filed on 10/14/1997US Classes:514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/8, Glycoprotein (carbohydrate containing)514/16, 7 or 8 peptide repeating units in known peptide chain514/17, 5 or 6 peptide repeating units in known peptide chain514/18, 3 or 4 peptide repeating units in known peptide chain514/34, Oxygen of the saccharide radical bonded directly to a polycyclo ring system of four carbocyclic rings (e.g., daunomycin, etc.)514/283, Ring nitrogen in the pentacyclo ring system is shared by five-membered cyclo and six-membered cyclo (e.g., vincamine, etc.)530/300, PEPTIDES OF 3 TO 100 AMINO ACID RESIDUES530/322, Peptides containing saccharide radicals, e.g., bleomycins, etc.530/328, 8 to 10 amino acid residues in defined sequence530/329, 6 to 7 amino acid residues in defined sequence530/330, 4 to 5 amino acid residues in defined sequence530/345, Chemical aftertreatment, e.g., acylation, methylation, etc.536/6.4, Daunomycin or derivative540/478Containing additional heterocyclic polycyclo ring system having plural ring nitrogens (e.g., vinblastine, vincristine, etc.)ExaminersPrimary: Russel, Jeffrey E.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 038/08A61K 038/14 C07K 007/06 C07K 009/00 AbstractChemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).Other References
Field of SearchPeptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAIGlycoprotein (carbohydrate containing) 7 or 8 peptide repeating units in known peptide chain 5 or 6 peptide repeating units in known peptide chain 3 or 4 peptide repeating units in known peptide chain Oxygen of the saccharide radical bonded directly to a polycyclo ring system of four carbocyclic rings (e.g., daunomycin, etc.) Ring nitrogen in the pentacyclo ring system is shared by five-membered cyclo and six-membered cyclo (e.g., vincamine, etc.) PEPTIDES OF 3 TO 100 AMINO ACID RESIDUES Peptides containing saccharide radicals, e.g., bleomycins, etc. 8 to 10 amino acid residues in defined sequence 6 to 7 amino acid residues in defined sequence 4 to 5 amino acid residues in defined sequence Chemical aftertreatment, e.g., acylation, methylation, etc. Daunomycin or derivative Nitrogen containing Containing additional heterocyclic polycyclo ring system having plural ring nitrogens (e.g., vinblastine, vincristine, etc.) |
| ||||||||||||||
