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Rat cathepsin K polynucleotide and polypeptide sequence

Patent 5948669 Issued on September 7, 1999. Estimated Expiration Date: Icon_subject February 26, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Human osteoclast-derived cathepsin Patent #: 5501969
Issued on: 03/26/1996
Inventor: Hastings, et al.

Inventors

Assignee

Application

No. 806959 filed on 02/26/1997

US Classes:

435/226, Derived from animal tissue (e.g., rennin, etc.)435/320.1, VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.)435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE536/23.2, Encodes an enzyme536/24.31Probes for detection of animal nucleotide sequences

Examiners

Primary: Carlson, Karen Cochrane

Attorney, Agent or Firm

Foreign Patent References

  • WO 9524182 WO. 09/13/1995
  • WO 9613523 WO. 05/13/1996
  • WO 9716177 WO. 05/13/1997

International Classes

C12N 005/10
C12N 009/64
C12N 015/57
C12N 015/63

Abstract

Rat cathepsin k polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rat cathepsin k polypeptides and polynucleotides in the design of protocols for the treatment of osteoporosis, periodonatal disease, arthritis, cancer, tumor metastasis, and Paget's disease, among others, and diagnostic assays for such conditions.

Other References

  • Shi et al., "Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2", FEBS Letters, 357, pp. 129-134 (1995)
  • Accession No. AF010306, Payne et al., "Rattus norvegicus cathepsin K mRNA" (1997)
  • Rantakokko et al., FEBS Letters 393:307-313, 1996
  • Tezuka et al., J. Biol. Chem. 269:1106-1109, 1994
  • Hadman et al., Oncogene 12:135-142, 1996
  • Hill et al., J. Cell. Biochem. 56:118-130, 1994
  • Gelb et al., Science 273:1236-1238, 1996
  • Drake, et al., "Identification of a Novel Osteoclast-Selective Human Cystein Proteinase", J. Bone Miner. Res., 9:S177, 199
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