Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use
Patent 5942543 Issued on August 24, 1999. Estimated Expiration Date: December 16, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/537, With an additional active ingredient514/535, The nitrogen of the Z radical is directly bonded to a benzene ring which is directly bonded to the C(=O) group514/536, With an agent to enhance topical absorption or with a stabilizing agent514/626, Nitrogen in R514/817ANESTHETIC, TOPICAL
A topical anesthetic includes about 1-10% by weight lidocaine hydrochloride, about 0.01-0.10% by weight adrenaline, and about 0.25-4% by weight tetracaine hydrochloride, preferably in an aqueous base with about 2% benzyl alcohol or in a gel including about 3% hydroxyethyl cellulose. The topical anesthetic has been found to be at least as effective as TAC (tetracaine hydrochloride, adrenaline, cocaine), but with fewer harmful side effects and at a greatly reduced cost (about 1/10 of the cost of TAC).
Other References
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Schilling, C.G. et al., "Tetracaine, Epinephrine, Cocaine (TAC) vs Lidocaine, Epinephrine, Tetracaine (LET) for Anesthesia of Lacerations in Children", American Journal of Diseases of Children, (Apr. 1993), p. 427, No. 48
Schilling, C.G. et al., "Tetracaine, Epinephrine, Cocaine (TAC) vs Lidocaine, Epinephrine, Tetracaine (LET) for Anesthesia of Lacerations in Children", Annals of Emergency Medicine, (Feb. 1995), p. 203
Ernst, Amy A. et al., "Lidocaine Adrenaline Tetracaine Gel Versus Tetracaine Adrenaline Cocaine Gel for Topical Anesthesia in Linear Scalp and Facial Lacerations in childres Aged 5 to 17 Years", Pediatrics, (Feb. 1995), pp. 255-258
Ernst, Amy A. et al., "LAT (Lidocaine-Adrenaline-Tetracaine) Versus TAC (Tetracaine-Adrenaline-Cocaine) for Topical Anesthesia in Face and Scalp Lacerations", American Journal of Emergency Medicine, (Mar. 1995) pp. 151-15
December 16, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
