U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use

Patent 5942543 Issued on August 24, 1999. Estimated Expiration Date: Icon_subject December 16, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3868445

3898339

Pharmaceutical local anesthetic compositions
Patent #: 3957996
Issued on: 05/18/1976
Inventor: Adams ,   et al.

Potentiated medicaments
Patent #: 4006218
Issued on: 02/01/1977
Inventor: Sipos

Pharmaceutical local anesthetic composition
Patent #: 4029794
Issued on: 06/14/1977
Inventor: Adams ,   et al.

Aminotetralins and use in inducing anesthesia
Patent #: 4057582
Issued on: 11/08/1977
Inventor: Dunnigan ,   et al.

Local anaesthetic salts of chondroitinsulfate compounds
Patent #: 4105760
Issued on: 08/08/1978
Inventor: Szejtli ,   et al.

Osmotic system with distribution zone for dispensing beneficial agent
Patent #: 4200098
Issued on: 04/29/1980
Inventor: Ayer ,   et al.

Process for manufacturing device with dispersion zone
Patent #: 4285987
Issued on: 08/25/1981
Inventor: Ayer ,   et al.

Dispenser with diffuser
Patent #: 4320759
Issued on: 03/23/1982
Inventor: Theeuwes

More ...

Inventor

Application

No. 766994 filed on 12/16/1996

US Classes:

514/537, With an additional active ingredient514/535, The nitrogen of the Z radical is directly bonded to a benzene ring which is directly bonded to the C(=O) group514/536, With an agent to enhance topical absorption or with a stabilizing agent514/626, Nitrogen in R514/817ANESTHETIC, TOPICAL

Examiners

Primary: Burn, Brian M.

Attorney, Agent or Firm

International Class

A61K 031/24

Abstract

A topical anesthetic includes about 1-10% by weight lidocaine hydrochloride, about 0.01-0.10% by weight adrenaline, and about 0.25-4% by weight tetracaine hydrochloride, preferably in an aqueous base with about 2% benzyl alcohol or in a gel including about 3% hydroxyethyl cellulose. The topical anesthetic has been found to be at least as effective as TAC (tetracaine hydrochloride, adrenaline, cocaine), but with fewer harmful side effects and at a greatly reduced cost (about 1/10 of the cost of TAC).

Other References

  • Adriani et al., "Fatalities following topical application of local anesthetics to mucous membranes", JAMA 1956; 162 (17): 1527-1530
  • Campbell et al., "Absorption of local anethetics", JAMA 1958; 168(7): 873-877
  • Adriani, "The clinical pharmacology of local anesthetics" Clinical Pharmacology and Therapeutics, vol. I, No. 5, 645-673 (1960)
  • Adriani et al., "Clinical effectiveness of drugs used for topical anesthesia",. JAMA 1964; 188(8): 711-716
  • DiFazio, "Local anesthetics: Action, metabolism and toxicity", Otolaryngologic Clinics of North America, 1981; 14(3): 515-519
  • Mofenson et al., "Lidocaine toxicity from topical mucosal application", Clinical Pediatrics, Mar. 1983; 22(3): 190-192
  • Beyer et al., "Systemic Toxicity from Tetracaine Pharyngeal Anesthesia", Digestive Diseases and Sciences, vol. 35, No. 2 (Feb. 1990), p. 280
  • Wase et al., "XAP--an Alternative to Cocaine for Topical Anesthesia", Annals of Emergency Medicine, 22:11 (Nov. 1993), pp. 1776-1777
  • Schilling, C.G. et al., "Tetracaine, Epinephrine, Cocaine (TAC) vs Lidocaine, Epinephrine, Tetracaine (LET) for Anesthesia of Lacerations in Children", American Journal of Diseases of Children, (Apr. 1993), p. 427, No. 48
  • Schilling, C.G. et al., "Tetracaine, Epinephrine, Cocaine (TAC) vs Lidocaine, Epinephrine, Tetracaine (LET) for Anesthesia of Lacerations in Children", Annals of Emergency Medicine, (Feb. 1995), p. 203
  • Ernst, Amy A. et al., "Lidocaine Adrenaline Tetracaine Gel Versus Tetracaine Adrenaline Cocaine Gel for Topical Anesthesia in Linear Scalp and Facial Lacerations in childres Aged 5 to 17 Years", Pediatrics, (Feb. 1995), pp. 255-258
  • Ernst, Amy A. et al., "LAT (Lidocaine-Adrenaline-Tetracaine) Versus TAC (Tetracaine-Adrenaline-Cocaine) for Topical Anesthesia in Face and Scalp Lacerations", American Journal of Emergency Medicine, (Mar. 1995) pp. 151-15
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