Patent ReferencesDirect compression cyclophosphamide tablet Solid pharmaceutical preparations of active form of vitamin D3 of improved stability Dry mix formulation for bisphosphonic acids with lactose Bisphosphonates prevent bone loss associated with immunosuppressive therapy Dosage forms of risedronate Dry mix formulation for bisphosphonic acids Polymorphic forms of a growth hormone secretagogue Patent #: 5767124 InventorsAssigneeApplicationNo. 820430 filed on 03/12/1997US Classes:424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/463, Coated capsules424/482, Containing solid synthetic polymers424/486, Synthetic polymer424/490Coated (e.g., microcapsules)ExaminersPrimary: Levy, Neil S.Assistant: Benston, William E. Jr. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/14AbstractThe present invention is directed to a novel enteric-coated oral dosage form of a risedronate active ingredient comprised of a safe and effective amount of a pharmaceutical compostion which is comprised of a risedronate active ingredient and pharmaceutically-acceptable excipients. Said dosage forms prohibit the exposure of the risedronate active ingredient to the epichelial and mucosal tissues of the buccal cavity, pharynx, esophagus, and stomach and thereby protects said tissues from erosion, ulceration or other like irritation. Accordingly, the said dosage forms effect the delivery to the lower intestinal tract of said human or other mammal of a safe and effective amount of the risedronate active ingredient, and substantially alleviate the esophagitis or esophageal irritation which sometimes accompanies the oral administration of risedronate active ingredients.Field of SearchParticulate form (e.g., powders, granules, beads, microcapsules, and pellets)Synthetic polymer Containing solid synthetic polymers Coated capsules Polysaccharides (e.g., cellulose, etc.) Sustained or differential release type Coated (e.g., microcapsules) Two or more phosphorus atoms directly or indirectly bonded together by only covalent bonds Spiro ring system | |