Patent 5928671 Issued on July 27, 1999. Estimated Expiration Date: June 26, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A composition comprising a trivalent bismuth salt, particularly bismuth nitrate, and dimercaprol is described. Methods for using the composition as a bacteriocidal and bacteriostatic agent and as a disinfectant and preservative are also provided.
Other References
W. Beil et al., Pharmacology 50:333-337 (1995)
D.W. Bierer, Rev. Infect. Dis. 12(1):S3-S8 (1990)
D. Chaleil et al., J. Inorg. Biochem. 15:213-221 (1981)
N.A. Cornick et al., Rev. Infec. Dis. 12(1):S9-S10 (1990)
J.S. Dixon, Scand. J. Gastroenterol. 30(212):48-62 (1995)
P. Domenico et al., J. Antimicro. Chemo. 28:801-810 (1991)
P. Domenico et al., Infection 20(2):18/66-23/71 (1992)
P. Domenico et al., Eur. J. Clin. Microbiol. Infec. Dis. 11:170-175 (1992)
P. Domenico, "Comparative Antibacterial Properties of Bismuth-Dimercaprol and Chlorhexidine," 95th Gen'l. Meeting Amer. Soc. Microbiol., Washington, D.C. (May 1995)
P. Domenico et al., "Bismuth-Dimercaprol Activity Against Multiply Resistant Gram-Positive Bacteria," Clin. Res. Meeting, Abstract (May 1995)
P. Domenico et al., In vitro Antifungal Activities of BisBAL and BisME, Two Thiol-Chelated Bismuth Compounds, 36th ICAAC, Abstract F188 (Sep. 1996)
P. Domenico et al., "Efficacy/Toxicity of Bismuth-Dimercaprol in a Burn Wound Sepsis Model," 96th ASM General Meeting, Abstract A10 (May 1996)
P. Domenico et al., "Antimicrobial Activity of the Bismuth-Thiol Chelates, BisBAL and BisME," Clin. Res. 44:332A, Abstract (1996)
P. Domenico et al., Annals of N.Y. Acad. Sci. 797:269-270 (1996)
P. Domenico et al., Antimicrob. Agents and Chemo. 38(6):1031-1040 (1997)
P. Domenico et al., Antimicrob. Agents and Chemo. 41(8):1697-1703 (1997)
P. Domenico et al., "Potentiation of Bismuth Antibacterial Activity by Thiol Chelators," 97th ASM Gen'l. Meeting, Florida, Official Abstract Form & Abstract A-43 (May 1997)
B.E. Douglas et al., Concepts and Models of Inorganic Chem., 3rd Ed. pp. 463-465 1994)
H.L. DuPont et al., New Eng. J. Med. 328:1821-1827 (1993)
D. Figueroa-Quintanilla et al., New Eng. J. Med. 328(23):1653-1658 (1993)
S.L. Gorbach et al., Reviews of Infec. Dis. 12(1):S21-S23 (1990)
Gould et al., "Activity of the Novel Compounds BisBAL and BisME Against Burkholderia cepacia," 36th ICAAC, Louisiana, Abstract F246 (1996)
D.Y. Graham et al., Ann. Intern. Med. 115:266-269 (1991)
D.Y. Graham et al., Gastroenterol. 102:493-496 (1992)
W. Hespe et al., Gastroenterol. 104(4):1242-1243 (1993)
R. Husseini et al., Microbios 29(116):109-125 (1980)
R. Iffland, "Bismuth" in Metals in Clinical and Analytical Chemistry, Marcel Dekker, Inc. Chap. 21, pp. 269-281 (1994)
T. Klapotke, Biol. Metals 1:69-76 (1988)
M.D. Manhart, Reviews of Infec. Dis. 12(1):S11-S15 (1990)
B.J. Marshall, Reviews of Infec. Dis. 12(1):S87-S93 (1990)
Molina et al., Acta. Neurol. Scand. 79:200-203 (1989)
Molina et al., Med. Clinicas 93(1):20-22 (1989)
G.L. Newton et al., Methods of Enzymology, vol. 251, pp. 148-166, Academic Press (1995)
P-M. Roy et al., The Lancet 344:1708 (1994)
K.W. Shea et al., "Vancomycin Resistant Enterococci (VRE) Colonization in an Outpatient Hemodialysis (HD) Unit," 6th Ann. Mtg. of the Soc. for Healthcare Epidemiology of America, Official Abstract Form (Apr. 1996)
A. Slikkerveer et al., Med. Toxicol. Adverse Drug. Exp. 4(5):303-323 (1989)
A.P.R. Wilson, The Lancet 344:1313-1314 (1994)
"The Pharmacological Basis of Therapeutics, Heavy Metal Antagonists, Halogens and Halogen-Containing Compounds," 7th Ed., Goodman & Gilman, pp. 963-964 and 1621-1622 (1985)
Meta-Analysis of the Efficacy of Antibiotic Therapy in Eradicating Helicobacter pylori, Naoki Chiba, M.D.; Babu V. Rao, M.D.; Johan W. Rademaker, M.D.; and Richard H. Hunt, M.D.; The American Journal of Gastroenterology, vol. 87, No. 12, 1992, pp. 1716-1727
Studies on the Mechanism of Action of Colloidal Bismuth Subcitrate (1. Interaction with Sulfhydryls); W. Beil, S. Bierbaum, K.-F. Sewing; Pharmacology, 1993; 47:135-40
Studies on the Mechanism of Action of Colloidal Bismuth Subcitrate (2. Interaction with Pepsin); W. Beil, S. Bierbaum, K.-F. Sewing; Pharmacology, 1993; 47:141-144
Colloidal Bismuth Subcitrate: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Its Therapeutic Use in Peptic Ulcer Disease; Antona J. Wagstaff, Paul Benfield and Jon P. Monk; Drugs 36: 132-157 (1988)
P. Domenico & B.A. Cunha, "Synergistic Inhibitory Effects of Bismuth and Demercaprol Against Gram-Negative Bacteria", Apr. 26, 1994, 6th International Congress for Infectious Diseases, Prague, Czech Republic
P. Domenico & B.A. Cunha, "Mechanism of Bismuth-Dimercaprol Antimicrobial Synergy", Oct., 1994, 34th ICAAC, Orlando, Florid
June 26, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
