Method for dry blend compression of medicaments
Patent 5928668 Issued on July 27, 1999. Estimated Expiration Date: 
August 1, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 1, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3568828 Triphasic oral contraceptive Quick-liquifying, chewable tablet Defoaming composition Hormone preparation and method Process for providing therapeutic composition Patent #: 5595759 InventorsAssigneeApplicationNo. 649719 filed on 08/01/1996US Classes:424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/464, Tablets, lozenges, or pills424/465With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)ExaminersPrimary: Page, Thurman K.Assistant: Benston, W. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/14Foreign Application Priority Data1993-12-21 ZAAbstractDisclosed is a method of dry blend compression of potent drugs with low solubility, such as steroidal medicaments using directly compressible agglomerated excipients that are not a conventional or spray dried polyalcohol or lactose. The agglomerated excipients include mannitol, maltodextrin or corn syrup solids, which hold the medicament(s) in the crevices of the agglomerates. Also disclosed are the critical ratios of the agglomerated excipients to steroidal agent, specifically estradiol, that is distributed uniformly throughout the dry blend and then compressed into tablets. | |
