Chronic, bolus administration of D-threo methylphenidate
Patent 5922736 Issued on July 13, 1999. Estimated Expiration Date: September 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
Other References
Angrist et al., J. Clin. Psychopharm., 1992, 12(4), 268-272
White et al., J. Clin. Psychiatry, 1992, 53(5), 153-156
Aoyama et al., "Pharmacolinetics and pharmacodynamics of (+)-threo-methylphenidate enantiomer in patients with hypersomnia", Clin. Pharmacol. Ther., 1994, 55(3), 270-276
Bowden et al., "Reactions of Carbonyl Compounds in Basic Solutions the Alkaline Hydrolysis of N-Methyl, N-Phenyl, and Bicyclo Lactams Penicillins, and N-Alkyl-N-methylacetamides", J. Chem. Soc. Perkin Trans., 1990, 12, 2111-2116
Brown G., "The Use of Methylphenidate for Cognitive Decline Associated with HIV Disease", Int'l J. Psychiatry Med., 1995, 25(1), 21-37
Brown, "Pharmacological Action and Drug Development", Chirality in Drug Design and Synthesis, Academic Press Inc., 1990, 4-7
Corey et al., "A New Synthetic Approach to the Penicillins", J. Am. Chem. Soc., 1965, 87(11), 2518-2519
Ding et al., Cis-and trans-Axetidin-2-ones from Nitrones and Copper Acetylide, J. Chem. Soc. Perkin, 1976, 22, 2382-2386
Douzenis et al., "Phychiatric Disorder in HIV Disease: Description of 200 Referrals to a Liaison psychiatry Service", Proc 7th. Int'l Conf. AIDS, 1991, 215 (M.B.2135--Summary)
Earle et al., Synthesis and Hydrolysis of some Fused-ring ଲ-Lactams, J. Chem. Soc., 1969, 2093-2098
Hou, J.P. et al., "Beta-Lactam Antibiotics: Their Physiochemical Properties and Biological Activities in Relation to Structure", J. Pharm. Sci., 1971, 60(4), 503-532
Klibanov, "Asymmetric Transformations Catalyzed by Enzymes in Organic Solvents", Acc. Chem. Res., 1990, 23, 114-120
Moll F., "Darstellung von 1-Aza-bicyclo4.2.0!octan-2-on", Naturforsch Teil B., 1966, 21, 297
Navia et al., "The AIDS Dementia Complex: I. Clinical Features", Annals of Neurology, 1986, 19, 517-524
Patrick et al., "Pharmacology of the Enantiomers of threo-Methylphenidate", J. Pharmacol & Exp. Terhap., 1987, 241, 152-158
Rieder et al., "Diagnosis of Sulfonamide Hypersensitivity Reactions by In-Vitro "Rechallenge" with Hydroxylamine Metabolites", Ann. Intern Med., 1989, 100, 286-289
Srinivas et al., "Enantioselective Pharmacokinetics of dl-threo-Methylphenidate in Humans", Pharmacol Res., 1993, 10(1), 14-21
Srinivas et al., "Enantiomeric Gas Chromatography Assay with Electron Capture Detection for d-Ritalinic Acid in Plasma", J. Chromatagraph, 1990, 530, 327-336
Srinivas et al., "Sterioselective Disposition of Methylphenidate in Children with Attention Deficit Disorder", J. Pharmacol. Exp. Ther., 1987, 241(1), 300-306
Staal et al., "Glutathione deficiency and human immunodeficiency virus infection", Lancet, 1992, 339, 909-912
Uetrecht et al., "Idiosyncratic Drug Reactions: Possible Role of Reactive Metabolites Generated by Leukocytes", Pharmacol Res., 1989, 6(4), 265-273
White et al., "methylphenidate as a Treatment for Depression in Acquired Immunodeficiency Syndrome: An n-of-1 Trial", J. Clin. Psychiatry, 1992, 53(5), 153-15
September 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
