Urethane-containing aminosteroid compounds

Patent 5922703 Issued on July 13, 1999. Estimated Expiration Date:

July 13, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Amino-14 steroid derivatives and process for preparation of the same
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Patent #: 5144017
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Inventors

Assignee

The Procter & Gamble Company

Application

No. 126293 filed on 09/24/1993

US Classes:

514/182, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system552/515Nitrogen bonded directly to the cyclopentanohydrophenanthrene ring system

Examiners

Primary: Dees, Jose G.
Assistant: Badio, Barbara P.

Attorney, Agent or Firm

McMahon; Mary Pat, Winter; William J., Clark; Karen F.

Foreign Patent References

2642973 FR. 08/13/1987
296 502A5 DE. 04/13/1979
256 134A1 DE. 06/13/1985
4-29089 JP. 10/13/1992
WO87/04168 GB. 07/13/1987
WO87/04167 GB. 07/13/1987
WO91/17176 WO. 11/13/1991

International Classes

A61K 031/56
C07J 041/00

Abstract

Urethane-containing amino steroids having the general chemical formula: ##STR1## wherein a, b, R1, R2, R3, R4, R14 and Z are as defined in the specification. Also disclosed are pharmaceutical composition and the use of the compounds/composition in the treatment of congestive heart failure.

Other References

DiBianco, R., et al., "A Comparison of Oral Milrinone, Digoxin, and their Combination in the Treatment of Patients with Chronic Heart Failure", 320 N. Engl. J. Med. 677 (1989)
Goodman and Gilman, The Pharmacological Basis of Therapeutics, Chapter 34, (8th Ed., 1990)
Nicklas, J. M. and Pitt, B., et al. (The SOLVID Investigators) "Effect of Enalapril on Survival in Patients with Reduced Left Ventrical Ejection Fractions and Congestive Heart Failure", 325(5) N. Engl. J. Med. 293 (1991)
Templeton, J. et al., "Synthesis of 20-Hydroxy-, 20-Amino-, and 20-Nitro-14-hydroxy-21-nor-5ଲ, 14ଲ-pregnane C-3 Glycosides and Related Derivatives: Structure-Activity Relationships of Pregnanes That Bind to the Digitalis Receptor", 36 J. Med. Chem. 42-45 (1993)
Templeton, J. et al., "Synthesis of 20଱- and 20ଲ-Acetamido, Amino, Nitro and Hydroxy Derivatives of 14-Hydroxy-5ଲ, 14ଲ=pregnane 3ଲ-Glycosides: Pregnanes that Bind to the Digitalis Receptor", 1 J. Chem. Soc. Perkin Trans. 2503-2517 (1992)
Adeoti, S., et al., "Introduction of A 14ଲ-Nitrated Function Into The Steroid Ring To Prepare The Cardioactive Molecule, 14ଲ-Amino-5ଲ-Pregnane3ଲ, 20ଲ-Diol, From Progesterone and Deoxycholic Acid", 45 (12), Tetradhedron 3717-3730 (1989) (English Translation