Composition and method of preparing microparticles of water-insoluble substances
September 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for preparing ethylcellulose microcapsules Drug delivery compositions and methods Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants Silicone vesicles and entrapment Solid care therapeutic compositions and methods for making same Method of making nanoparticulate X-ray blood pool contrast agents using high molecular weight nonionic surfactants Patent #: 5447710 InventorsAssigneeApplicationNo. 939699 filed on 09/29/1997US Classes:424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/450, Liposomes424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/464, Tablets, lozenges, or pills424/468Sustained or differential release typeExaminersPrimary: Page, Thurman K.Assistant: Benston, William E. Jr. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/14AbstractSubmicron size particles of pharmaceutical or other water-insoluble or poorly water-insoluble substances are prepared using a combination of one or more surface modifiers/surfactants such as polaxomers, poloxamines, polyoxyethylene sorbitan fatty acid esters and the like together with natural or synthetic phospholipids. Particles so produced have a volume weighted mean particle size at least one-half smaller than obtainable using a phospholipid alone. Compositions so prepared are resistant to particle size growth on storage. | |
