U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Aerosol formulations containing P134a and particulate medicament

Patent 5922306 Issued on July 13, 1999. Estimated Expiration Date: Icon_subject April 15, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2868691

2885427

3014844

3219533

3320125

3809294

3897779

Aerosol propellant compositions
Patent #: 4174295
Issued on: 11/13/1979
Inventor: Bargigia ,   et al.

Composition for treating asthma
Patent #: 4405598
Issued on: 09/20/1983
Inventor: Brown

Aerosol formulations containing P134a and particulate medicaments
Patent #: 5653962
Issued on: 08/05/1997
Inventor: Akehurst, et al.

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Inventors

Assignee

Application

No. 060110 filed on 04/15/1998

US Classes:

424/45, Organic pressurized fluid424/46, Powder or dust containing514/826, ASTHMA514/937DISPERSION OR EMULSION

Examiners

Primary: Bawa, Raj

Attorney, Agent or Firm

Foreign Patent References

  • 0 504 112 EP. 09/13/1992
  • 27 03 119 DE. 10/13/1990
  • 90/07333 WO. 07/13/1990

International Class

A61K 009/12

Foreign Application Priority Data

1991-12-12 GB

Abstract

A pharmaceutical formulation comprising (i) one or more particulate medicaments, and (ii) 1,1,1,2-tetrafluoroethane as propellant, which formulation contains less than 0.0001% w/w surfactant based upon the weight of medicament, particulate medicament being present in an amount from 0.005 to 5% w/w relative to the total weight of the formulation and having a particle size of less than 100 microns, with the proviso that said medicament is other than salmeterol, salbutamol, fluticasone propionate, beclomethasone dipropionate or a physiologically acceptable salt or solvate thereof and with the proviso that when said formulation consists of betamethasone, ergotamine tartrate or sodium cromoglycate and 1,1,1,2-tetrafluoroethane the weight to weight ratio of medicament to propellant is other than 69:7900 or 0.866% w/w.

Other References

  • Oberholz, Frankfurter Allegmeine Zeitung, Oct. 1989, vol. 25, No. 207, p. 7
  • Dalby et al., Pharmaceutical Technology, Mar. 1990, vol. 14, No. 3, pp. 26-33
  • Amzacort™ carton, William H. Rorer, Inc., Fort Washington, Pennsylvania, USA 19034, 1986
  • Pharmaceutical Journal, Sep. 29, 1990, vol. 245, pp. 428-429,
  • The Theory and Practice of Industrial Pharmacy, 2nd Ed., 1976 (Philadelphia, PA: Lea and Febiger), pp. 270 and 276-278
  • Handbook of Aerosol Technology, 2nd Edition, 1979 (New York, New York: Van Nostrand Reinhold Company), pp. 30, 32, 33, 166, 167, 232, 233
  • U.S. Senate Hearings, May 12-14, 1987, 343-347, 437 (U.S. Government Printing Office, Washington, D.C., 1987), CIS:1987-S321-26
  • Hagers Handbook of Pharmaceutical Practice, 1971, pp. 342-354 (Berlin: Springer-Verlag
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