Method for treating asthma using optically pure R(-) salmeterol

Patent 5919827 Issued on July 6, 1999. Estimated Expiration Date:

December 17, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Phenethanolamine derivatives Patent #: 4992474
Issued on: 02/12/1991
Inventor: Skidmore, et al.

Inventors

Assignee

Sepracor Inc.

Application

No. 992376 filed on 12/17/1997

US Classes:

514/651, Ether oxygen is part of the chain514/649Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain

Examiners

Primary: Jarvis, William R. A.

Attorney, Agent or Firm

Heslin & Rothenberg, P.C.

Foreign Patent References

0422889 EP. 04/13/1991
2140800 GB. 12/13/1984

International Class

A61K 031/135

Abstract

The optically pure R(-) isomer of salmeterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of salmeterol for treating asthma while minimizing toxicity and other side effects associated with salmeterol.

Other References

J. Morley et al., Effects of (+) and Racemic Salmutamol on Airway Responses in the Guinnea-Pig, BR. J. Pharmaca., 104, Proc. Supp. (1991)
Larsson, Chem. Abst. 114(3): 1694lr; "Long-term Studies on Long Acting Sympathomimetics", Lung 168 (Suppl), 22-24 (1990)
Johnson, Chem. Abst. 114(3): 16944u: "The Pharmacology of Salmeterol", Lung 168 (Suppl.) 115-119 (1990)
Chem. Abst. 114 (7): 55571q; Brittain, "Approaches to a Long-Acting, Selective beta₂ -adrenoceptor Stimulant", Lung 168 (Suppl.), 111-114 (1990)
World Patent Index Acc. No.: 84-264874/43; DE 3414752, Oct. 18, 1984, Skidmore et al., New Phenyl Amino Ethanol Derivative
Jamali et al., "Enantioselective Aspects of Drug Action and Disposition: Therapeutic Pitfalls", J. Pharma. Sci. 78(9), 695-711 (1989