Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imaging
March 14, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesCarrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics Lipisomes containing gas for ultrasound detection Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same Stable microbubbles suspensions injectable into living organisms Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof Ultrasonic contrast agents for color Doppler imaging Biodegradable injectable nanoparticles Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas Stabilized microbubble compositions Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent Patent #: 5730954 InventorsAssigneeApplicationNo. 602797 filed on 03/14/1997US Classes:424/9.52, Stable gas bubbles containing or intentional solubilized gas containing424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/501, Contains solid synthetic resin427/213.3, Solid encapsulation process utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)427/213.36, Solid-walled microcapsule formed from preformed synthetic polymer428/402.21Solid-walled microcapsule from synthetic polymerExaminersPrimary: Dees, Jose G.Assistant: Hartley, Michael G. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 049/04A61K 009/16 B01J 013/02 B32B 005/16 Foreign Application Priority Data1993-09-03 GBAbstractThe present invention relates to polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerizable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I):--(O)m --CO--O--C(R1 R2)--O--CO--(O)n --(I)where R1 and R2 each represent a hydrogen atom or a carbon-attached monovalent organic group, or R1 and R2 together form a carbon-attached divalent organic group and m and n are each zero or 1.Other References
Field of SearchStable gas bubbles containing or intentional solubilized gas containingLiposome containing Ultrasound contrast agent Capsules (e.g., of gelatin, of chocolate, etc.) Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) Coated (e.g., microcapsules) Containing solid synthetic polymers ENCAPSULATING NORMALLY LIQUID MATERIAL Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome) FORMATION OF SOLID PARTICULATE MATERIAL DIRECTLY FROM MOLTEN OR LIQUID MASS (E.G., LIQUID COMMINUTING) Contrast enhancement Solid encapsulation process utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome) Solid-walled microcapsule formed from preformed synthetic polymer Solid-walled microcapsule from synthetic polymer | |
