U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Aerosol formulations containing P134A and/or P227 and particulate medicament

Patent 5916540 Issued on June 29, 1999. Estimated Expiration Date: Icon_subject April 6, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2868691

2885427

3014844

3219533

3320125

3809294

3897779

Aerosol propellant compositions
Patent #: 4174295
Issued on: 11/13/1979
Inventor: Bargigia ,   et al.

Composition for treating asthma
Patent #: 4405598
Issued on: 09/20/1983
Inventor: Brown

Drug-containing chlorofluorocarbon aerosol propellent formulations
Patent #: 4814161
Issued on: 03/21/1989
Inventor: Jinks ,   et al.

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Inventors

Assignee

Application

No. 055253 filed on 04/06/1998

US Classes:

424/45, Organic pressurized fluid424/46, Powder or dust containing514/937DISPERSION OR EMULSION

Examiners

Primary: Bawa, Raj

Attorney, Agent or Firm

Foreign Patent References

  • 0 372 777 EP. 06/13/1990
  • 0 504 112 EP. 09/13/1992
  • 27 03 119 DE. 10/13/1990
  • 86/04233 WO. 07/13/1986
  • 90/07333 WO. 07/13/1990
  • 91/04011 WO. 04/13/1991
  • 91/11495 WO. 08/13/1991
  • 91/11173 WO. 08/13/1991
  • 91/11496 WO. 08/13/1991
  • 91/14422 WO. 10/13/1991
  • 92/00107 WO. 01/13/1992
  • 92/06675 WO. 04/13/1992
  • 92/08446 WO. 05/13/1992
  • 92/08447 WO. 05/13/1992
  • 92/11190 WO. 07/13/1992
  • 92/22288 WO. 12/13/1992
  • 92/22287 WO. 12/13/1992
  • 93/11743 WO. 06/13/1993
  • 93/11745 WO. 06/13/1993
  • 93/11747 WO. 06/13/1993
  • 93/11744 WO. 06/13/1993

International Class

A61K 009/12

Abstract

A pharmaceutical aerosol formulation comprising (i) particulate medicament, (ii) 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3,-heptafluoro-n-propane or a mixture thereof as propellant, and (iii) 0.01 to 5% w/w based upon the propellant of a polar cosolvent, the particulate medicament being present in an amount from 0.005% to 5% w/w relative to the total weight of the formulation and having a particle size of less than 100 microns, and which formulation contains less than 0.0001% w/w surfactant based upon the weight of medicament.

Other References

  • Oberholz, Frankfurter Allgemeine Zeitung, Oct. 1989, vol. 25, No. 207, p. 7
  • Dalby et al., Pharmaceutical Technology, Mar. 1990, vol. 14, No. 3, pp. 26-33
  • Amzacort™ carton, William H. Rorer, Inc., Fort Washington, Pennsylvania, USA 19034, 1986
  • Pharmaceutical Journal, Sep. 29, 1990, vol. 245, pp. 428-429
  • The Theory and Practice of Industrial Pharmacy, 2nd Ed., 1976 (Philadelphia, PA: Lea and Febiger), pp. 270 and 276-278
  • Handbook of Aerosol Technology, 2nd Edition, 1979 (New York, New York: Van Nostrand Reinhold Company), pp. 30, 32, 33, 166, 167, 232, 233
  • U.S. Senate Hearings, May 12-14, 1987, 343-347, 437 (U.S. Government Printing Office, Washington, D.C., 1987), CIS:1987-S321-26
  • Hagers Handbook of Pharmaceutical Practice, 1971, pp. 342-354 (Berlin: Springer-Verlag
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