Method of producing a virus vaccine from an African green monkey kidney cell line

Patent 5911998 Issued on June 15, 1999. Estimated Expiration Date:

January 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Sub-human primate diploid cell lines as substrates for virus vaccine production
Patent #: 4040905
Issued on: 08/09/1977
Inventor: Petricciani , et al.

Genetic reassortment of rotaviruses for production of vaccines and vaccine precursors
Patent #: 4571385
Issued on: 02/18/1986
Inventor: Greenberg , et al.

Growth of hepatitus A virus in vero cells Patent #: 4783407
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Inventors

Assignee

Application

No. 790598 filed on 01/29/1997

US Classes:

424/205.1, Reassortant or deletion mutant virus424/204.1, Virus or component thereof424/215.1, Reoviridae (e.g., rotavirus, reovirus, orbivirus, avian proventriculitis virus, bluetongue virus, Colorado tick fever virus, etc.)424/217.1Poliovirus

Examiners

Primary: McKelvey, Terry

Attorney, Agent or Firm

Burns, Doane, Swecker & Mathis, L.L.P.

International Classes

A61K 039/12
A61K 039/13
A61K 039/15

Abstract

A method for producing novel African Green Monkey Kidney (AGMK) cell lines is taught. These cell lines which are free of viable adventitious microbial agents are useful as substrates for viruses and for the preparation of viral vaccines.

Other References

Journal of General Virology, vol. 57, issued 1981, Lee et al., "Serial Propagation of Astrovirus in Tissue Culture with the Aid of Trypsin", pp. 421-424
Abstracts of the Annual Meeting of the American Society of Microbiology, 23rd Annual Meeting, issued Mar. 1983, Price et al, "The Use of Serially Propagated Monkey Kidney Cell Cultures for the Preparation of High-Titered Hemagglutinin and/or Complement-Fixing Antigens of the Human Parainfluenza Viruses-Types 1, 2 and 3", p. 299, col. 2, abstract T22
Biologicals, vol. 23, No. 3, issued Sep. 1995, Horaud, "Viral Vaccines and Residual Cellular DNA", pp. 225-228, see p. 227, col. 1
Abstract Annual Meeting Am. Soc. Microbiol., 1983 p. 299, Price et al, Abstract T22
Morbidity and Mortality Weekly Report, vol. 40(16): pp. 1-24, Apr. 27, 1991, (Unnamed Author(s))
Monroe et al, J. of Virology, Feb., 1991, vol. 65(2): pp. 641-64