U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method of intrapulmonary administration of a narcotic drug

Patent 5910301 Issued on June 8, 1999. Estimated Expiration Date: Icon_subject March 7, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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Aerosol formulations containing P134a and salbutamol Patent #: 5674471
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Inventors

Assignee

Application

No. 813094 filed on 03/07/1997

US Classes:

424/45, Organic pressurized fluid424/46Powder or dust containing

Examiners

Primary: Bawa, Raj

Attorney, Agent or Firm

Foreign Patent References

  • 3602370 DE. 08/13/1987
  • 2 255 918 GB. 11/13/1992
  • 2 256 805 GB. 04/13/1994
  • 90/07333 WO. 07/13/1990

International Class

A61K 009/12

Abstract

An aerosol formulation of an aerosol propellant and a base form of a narcotic drug selected from the group consisting of fentanyl, sufentanil and remfentanyl is provided. Such a formulation allows for the drug to be dissolved within the propellant and used within a device which does not require the use of a lubricant. Formulations are also disclosed which include lubricants, wherein the lubricant and propellant are both either polar or both non-polar. Thus, the lubricant component does not act as a solvent or cosolvent, but rather acts as a lubricant for the valve used for dispersing the formulation to a patient. Typical non-polar propellants include chlorofluorocarbons, which are typically used in connection with non-polar lubricants such as saturated vegetable oils, e.g. fractionated coconut oils. Typical polar propellants include hydrofluoroalkanes, which are typically used in connection with polar lubricants such as polyethylene glycols.

Other References

  • Weinhold, L.L. et al., (1993) Pharmacol. Biochem. Behav. 44(1):141-144
  • Jaffe, A.B. et al., (1989) Psychopharmacology 99(3):289-293
  • Newman, S.P. et al., (1981) Eur. J. Respir. Dis. 62:3-21
  • Newman, S.P., et al., "How should a pressurized ଲ-adrenergic bronchodilator be inhaled?", Eur. J. Respir. Dis., 62:3-21, (1981
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