Patent References 3812854 Drug-containing chlorofluorocarbon aerosol propellent formulations Medicinal aerosol formulations Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations Medicinal aerosol formulations Methods and devices for treating plumonary vasoconstriction and asthma Atomising devices and methods Prilocaine and hydrofluourocarbon aerosol preparations Butixocort aerosol formulations in hydrofluorocarbon propellant Aerosol formulations containing P134a and salbutamol Patent #: 5674471 InventorsAssigneeApplicationNo. 813094 filed on 03/07/1997US Classes:424/45, Organic pressurized fluid424/46Powder or dust containingExaminersPrimary: Bawa, RajAttorney, Agent or FirmForeign Patent References
International ClassA61K 009/12AbstractAn aerosol formulation of an aerosol propellant and a base form of a narcotic drug selected from the group consisting of fentanyl, sufentanil and remfentanyl is provided. Such a formulation allows for the drug to be dissolved within the propellant and used within a device which does not require the use of a lubricant. Formulations are also disclosed which include lubricants, wherein the lubricant and propellant are both either polar or both non-polar. Thus, the lubricant component does not act as a solvent or cosolvent, but rather acts as a lubricant for the valve used for dispersing the formulation to a patient. Typical non-polar propellants include chlorofluorocarbons, which are typically used in connection with non-polar lubricants such as saturated vegetable oils, e.g. fractionated coconut oils. Typical polar propellants include hydrofluoroalkanes, which are typically used in connection with polar lubricants such as polyethylene glycols.Other References
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