US Patent 5908850 - Method of treating attention deficit disorders with d-threo methylphenidate

US Patent Issued on June 1, 1999
Estimated Patent Expiration Date:

April 2, 2017Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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loading... View Patent Images (PDF) (Registered users only) Abstract Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof. Other References Angrist et al. Journal of Clinical Phsychopharmacology, 1992 12:268-272 Barkley et al. Pediatrics 1990 86:184-192 Barkley et al. Pediatrics 1991 87:519-531 Golinko Neuro-Psychopharmacol. & Biol Phsychiat 1984 8:1-8 Greenhill Pediatric Psychopharmacology 1992 15:1-27 Scott Drug Safety 1993 8:149-159 White et al. J. Clin. Phsychiatry 1992 53:153-156 Biosis Abstract No.: 87129969 Holmes et al. Psychostimulant Response in Aids-Related Complex Patients J. Clin. Psychiatry 50(1):5-8 (1989) Biosis Abstract No.: 95066168 Srinivas et al. Enantioselective Pharmacolinetics and Pharmacodynamics of Racemic Threo-Methylphenidate in Children with Attention Deficit Hyperactivity Disorder Clin. Pharmacol. Ther 52(2):561-568 (1990) Bowden et al. Reactions of Carbonyl COmpounds in Basic SOlutions The Alkaline Hydrolysis of N-Methyl, N-Phenyl, and Bicyclo Lactams Penicillins, and N-Alkyl-N-methylacetamides J. Chem. Soc. Perkin Trans. 1990 12:2111-2116 Ding et al., Cis- and trans-Axetidin-2-ones from Nitrones and Copper Acetylide J. Chem. Soc. Perkin 1976 22:2382-2386 Brown, C. Chirality in Drug Design and Synthesis Academic Press Inc. 1990 4-7 Klibanov A.M. Asymmetric Transformations Catalyzed by Enzymes in Organic Solvents Acc. Chem. Res. 1990 23:114-120 Earle et al. J. Chem. Soc. 1969:2093 (1980) Srinivas et al. Enantiomeric Gas Chromatography Assay with Electron Capture Detection for d-Ritalinic Acid in Plasma, J. Chromatagraph 1990 530:327-336 Srinivas et al. Sterioselective Disposition of Methylphenidate in Children with Attention Deficit Disorder J. Pharmacol. Exp. Ther. 1987 241:300-306 Corey et al. J. Amer. Chem. Soc 1965 87:2518 Moll F. Naturforsch Teil B. 1966 21:297 White et al. J. Clin. Psychiatry 1992 53:153-156 Greenhill L. Attention-Deficit Hyperactivity Disorder Child & Adol. Psych. Clin. N.A., 1995 4:123-165 Navia et al. Annals of Neurology 1986 19:517-524 Douzenis et al. Proc 7th. Int'l. Conf. AIDS 1991 1:2135-2215 Aoyama et al. Pharmacolinetics and pharmacodynamics of (+)-threo-methylphenidate enantiomer in patients with hypersomnia Clin. Pharmacol. Ther 1994 55:270-276 Uetrecht et al. Pharmacol Res. 1989 6:265-273 Staal et al. Lancet 1992 339:909-912 Rieder et al. Ann. Intern Med. 1989 110:286-289 Patrick et al. J. Pharmacol & Exp. Terhap. 1987 241:152-158 Srinivas et al. Pharmacol Res. 1993 10:14-21 Brown G. Int'l J. Psychiatry Med. 1995 25:21-3	Inventors Zeitlin, Andrew L. Dariani, Maghsoud M. Stirling, David I. Assignee Celgene Corporation Application No. 827230 filed on 04/02/1997 US Classes: 514/315Piperidines Field of Search 514/315Piperidines Examiners Primary: Henley, III, Raymond Attorney, Agent or Firm Woodcock Washburn Kurtz Mackiewicz & Norris LLP US Patent References 2507631, 2957880, 4992445, Transdermal delivery of pharmaceuticals Issued on: 02/12/1991 Inventor: Lawter, et al.5104899, Methods and compositions for treating depression using optically pure fluoxetine Issued on: 04/14/1992 Inventor: Young, et al.5114946, Transdermal delivery of pharmaceuticals Issued on: 05/19/1992 Inventor: Lawter, et al.5217718, Method and device for administering dexmedetomidine transdermally Issued on: 06/08/1993 Inventor: Colley, et al.5283193, Process for producing optically active ଱-substituted organic acid and microorganism and enzyme used therefor Issued on: 02/01/1994 Inventor: Yamamoto, et al.5284769, Process for preparing a single enantiomer of a lactam using lactamase Issued on: 02/08/1994 Inventor: Evans, et al.5331000, Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen Issued on: 07/19/1994 Inventor: Young, et al.5362755, Method for treating asthma using optically pure (R)-albuterol Issued on: 11/08/1994 Inventor: Barberich, et al.5375693, Methods and compositions for treating allergic disorders and other disorders metabolic derivatives of terfenadine Issued on: 12/27/1994 Inventor: Woosley, et al.5449743Method for ring opening polymerization using a hydrolase catalyst Issued on: 09/12/1995 Inventor: Kobayashi, et al. Foreign Patent References WO 97/03671 WO. 02/16/1997 WO 97/03672 WO. 02/16/1997 WO 97/03673 WO. 02/16/1997 International Class A61K 031/445

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US Patent 5908850 - Method of treating attention deficit disorders with d-threo methylphenidate

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