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Protein from urine named component B

Patent 5908827 Issued on June 1, 1999. Estimated Expiration Date: Icon_subject January 22, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Parital primary amino acid sequence of the antineoplastic protein (ANUP); a cytokine present in granulocytes Patent #: 5298604
Issued on: 03/29/1994
Inventor: Sloane

Inventor

Assignee

Application

No. 448561 filed on 01/22/1996

US Classes:

514/12, 25 or more peptide repeating units in known peptide chain structure435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide435/252.3, Transformants (e.g., recombinant DNA or vector or foreign or exogenous gene containing, fused bacteria, etc.)435/254.11, Transformants435/254.2, Yeast; media therefor435/320.1, VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.)530/412, Separation or purification536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/23.5, Encodes an animal polypeptide536/24.31Probes for detection of animal nucleotide sequences

Examiners

Primary: Prouty, Rebecca E.
Assistant: Longton, Enrique D.

Attorney, Agent or Firm

Foreign Patent References

  • 0 069 232 A3 EP. 01/13/1983
  • 82 04261 WO. 12/13/1982

International Class

A61K 038/00

Foreign Application Priority Data

1992-12-22 IT

Abstract

A new protein is described obtainable from urine through an extraction and purification process by ion-exchange chromatography and high resolution chromatography.

Other References

  • Accession No. R3O17 Cohen et al. (1993) Standard Protein; 131 AA
  • Accession No. Q2719O Lee et al. (1991) Standard cDNA; 1414 BP
  • Accession No. Q1O572 Chang M. et al. (1991) Standard DNA; 1047 BP
  • Sloane et al. (1986) Biochem. J., 234:355-362
  • R. Ridge et al, "Partial N-Terminal Amino Acid Sequence of the Anti-Neoplastic Urinary Protein (ANUP) and the Anti-Tumor Effect of the N-Terminal Nonapeptide of the Unique Cytokine Present in Human Granulocytes", Cytokine, vol. 8, No. 1 (Jan.), 1996 pp. 1-5
  • N. Sloane et al, "Studies on an Antineoplastic Fraction from Human Urine", Biochem. J. (1986) 234, pp. 355-362
  • Clinica Chimica Acta, vol. 207 (1992), pp. 239-249. A. Bernard et al., "Human Urinary protein 1: Evidence for identity with Clara cell protein and occurence in respiratory tract and urogenital secretions
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