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US Patent 5906934 - Mesenchymal stem cells for cartilage repair

US Patent Issued on May 25, 1999
Estimated Patent Expiration Date: Icon_subject May 25, 2016Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

It has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as well as polymer solutions. A presently preferred material is a polyglycolic acid mesh.

Other References

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Inventors

Assignee

Application

No. 403640 filed on 03/14/1995

US Classes:

435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE424/423, Surgical implant or material424/426, Errodable, resorbable, or dissolving435/349, Avian cell, per se435/380Releasing bound or adhered cell using protease

Field of Search

424/426, Errodable, resorbable, or dissolving424/423, Surgical implant or material435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE435/349, Avian cell, per se435/380Releasing bound or adhered cell using protease

Examiners

Primary: Criares, Theodore J.

Attorney, Agent or Firm

US Patent References

4352883, Encapsulation of biological material
Issued on: 10/05/1982
Inventor: Lim
4434094, Partially purified osteogenic factor and process for preparing same from demineralized bone
Issued on: 02/28/1984
Inventor: Seyedin ,   et al.
4774322, Polypeptide cartilage-inducing factors found in bone
Issued on: 09/27/1988
Inventor: Seyedin ,   et al.
4846835, Technique for healing lesions in cartilage
Issued on: 07/11/1989
Inventor: Grande
4968590, Osteogenic proteins and polypeptides
Issued on: 11/06/1990
Inventor: Kuberasampath, et al.
5041138, Neomorphogenesis of cartilage in vivo from cell culture
Issued on: 08/20/1991
Inventor: Vacanti, et al.
5133755, Method and apparatus for diodegradable, osteogenic, bone graft substitute device
Issued on: 07/28/1992
Inventor: Brekke
5197985, Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
Issued on: 03/30/1993
Inventor: Caplan, et al.
5226914, Method for treating connective tissue disorders
Issued on: 07/13/1993
Inventor: Caplan, et al.
5328695Muscle morphogenic protein and use thereof
Issued on: 07/12/1994
Inventor: Lucas, et al.

Foreign Patent References

  • WO 94/25080 WO. 11/18/1994

International Classes

C12N 005/00
C12N 005/02
A61F 002/00

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