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US Patent 5906934 - Mesenchymal stem cells for cartilage repair
US Patent Issued on May 25, 1999
Estimated Patent Expiration Date:
May 25, 2016Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
May 25, 2016Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractIt has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as well as polymer solutions. A presently preferred material is a polyglycolic acid mesh.Other References
| InventorsAssigneeApplicationNo. 403640 filed on 03/14/1995US Classes:435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE424/423, Surgical implant or material424/426, Errodable, resorbable, or dissolving435/349, Avian cell, per se435/380Releasing bound or adhered cell using proteaseField of Search424/426, Errodable, resorbable, or dissolving424/423, Surgical implant or material435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE435/349, Avian cell, per se435/380Releasing bound or adhered cell using proteaseExaminersPrimary: Criares, Theodore J.Attorney, Agent or FirmUS Patent References4352883, Encapsulation of biological materialIssued on: 10/05/1982 Inventor: Lim4434094, Partially purified osteogenic factor and process for preparing same from demineralized bone Issued on: 02/28/1984 Inventor: Seyedin , et al.4774322, Polypeptide cartilage-inducing factors found in bone Issued on: 09/27/1988 Inventor: Seyedin , et al.4846835, Technique for healing lesions in cartilage Issued on: 07/11/1989 Inventor: Grande4968590, Osteogenic proteins and polypeptides Issued on: 11/06/1990 Inventor: Kuberasampath, et al.5041138, Neomorphogenesis of cartilage in vivo from cell culture Issued on: 08/20/1991 Inventor: Vacanti, et al.5133755, Method and apparatus for diodegradable, osteogenic, bone graft substitute device Issued on: 07/28/1992 Inventor: Brekke5197985, Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells Issued on: 03/30/1993 Inventor: Caplan, et al.5226914, Method for treating connective tissue disorders Issued on: 07/13/1993 Inventor: Caplan, et al.5328695Muscle morphogenic protein and use thereof Issued on: 07/12/1994 Inventor: Lucas, et al. Foreign Patent References
International ClassesC12N 005/00C12N 005/02 A61F 002/00 |
