Supersaturated transdermal drug delivery systems, and methods for manufacturing the same

Patent 5906830 Issued on May 25, 1999. Estimated Expiration Date:

September 4, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Application

No. 708389 filed on 09/04/1996

US Classes:

424/448, Pressure sensitive adhesive means424/449Transdermal or percutaneous

Examiners

Primary: Page, Thurman K.
Assistant: Shelborne, Kathryne E.

Attorney, Agent or Firm

Foreign Patent References

0 144 486 A2 EP. 06/13/1985
0 391 172 A1 EP. 10/13/1990
0 497 626 A1 EP. 08/13/1992
217 989 DE. 01/13/1985
63093714 JP. 04/13/1988
WO 92 05811 WO. 04/13/1992
WO94/10984 WO. 05/13/1994
WO 97/09971 WO. 03/13/1997
WO 97/24148 WO. 07/13/1997

International Class

A61F 013/02

Abstract

Methods are provided for manufacturing transdermal drug delivery systems containing supersaturated drug reservoirs, such that higher drug fluxes are obtained. The methods involve heating the drug reservoir components to a predetermined temperature. Generally, this temperature is higher than the depressed melting temperature of the polymer-drug admixture which will serve as the drug reservoir. In an alternative embodiment, wherein heat treatment of the reservoir components results in a system having two liquid phases, the predetermined temperature is calculated so as to be higher than the melting temperature of the pure drug. Drug reservoirs and novel transdermal delivery systems prepared using the disclosed techniques are provided as well.

Other References

Akhtar et al., "The Influence of Crystalline Morphology and Copolymer Composition on Drug Release From Solution Cast and Melt-processed P(HB-HV) Copolymer Matrices," J. Controlled Release(1991) 17 (3):225-234 cript
Davis et al., "Effect of Supersaturation on Membrane Transport on Membrane Transport: 1. Hydrocortisone Actate," Intl. J. of Pharm. 76:1-8 (1991)
Pellet et al., "Effect of Supersaturation on Membrane Transport: 2. Piroxicam," Intl. J. of Pharm. 111:1-6 (1994