U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Antigen-processing cell-targeted conjugates

Patent 5898033 Issued on April 27, 1999. Estimated Expiration Date: Icon_subject December 19, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Acylated polyoxyalkylene polyamines
Patent #: 4151173
Issued on: 04/24/1979
Inventor: Vogel

Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal
Patent #: 4349530
Issued on: 09/14/1982
Inventor: Royer

Time-release chemical delivery system
Patent #: 4356166
Issued on: 10/26/1982
Inventor: Peterson ,   et al.

Cell-specific glycopeptide ligands
Patent #: 4386026
Issued on: 05/31/1983
Inventor: Ponpipom ,   et al.

Fiber optic dosimeter system using electron trapping materials
Patent #: 5030834
Issued on: 07/09/1991
Inventor: Lindmayer, et al.

5118784

Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system Patent #: 5225182
Issued on: 07/06/1993
Inventor: Sharma

Inventors

Application

No. 994334 filed on 12/19/1997

US Classes:

514/224.2, Polycyclo ring system having the six-membered hetero ring as one of the cyclos (e.g., 1,3- and 1,4- benzothiazines, etc.)514/570, Carboxy or salt thereof only attached indirectly to the benzene ring514/616, Plural carboxamide groups or plural C=O groups bonded directly to the same nitrogen514/814, ANEMIA514/825, ARTHRITIS528/328From N-C-(C=O)-OH containing reactant or acid derivative thereof, e.g., alpha amino acid, etc.

Examiners

Primary: MacMillan, Keith D.

Attorney, Agent or Firm

Foreign Patent References

  • 0 094 844 EP 11/13/1983
  • 0 485 158 EP 11/13/1991
  • 0 485 157 EP 11/13/1991
  • WO 87/03891 WO 07/13/1987
  • WO 92/05802 WO 04/13/1992
  • WO 92/19248 WO. 11/13/1992

International Classes

A61K 031/19
A61K 031/54

Abstract

An anti-inflammatory conjugate including a polyamino acid backbone, a non-steroidal anti-inflammatory agent, and a moiety linking the anti-inflammatory agent to the backbone, wherein the polyamino acid backbone has a molecular weight greater than 250 kD.

Other References

  • De Marre, et al., "Evaluation of the hydrolytic and enzymatic stability of macromolecular Mitomyci C derivatives", Journal of Controlled Release, 31:89-97, (1994)
  • Franssen, et al., "Hepatic and Intrahepatic Targeting . . . And Neoglycoproteins As Carrier Molecules", Biochemical Pharmacology, 45:1215-1226, (1993)
  • Liso, et al., "Antinociceptive and antipyretic properties . . . controlled delivery system", Journal of Controlled Release, 33:429-436, (1994)
  • Roos, et al., "Physicochemical and antitumor . . . of mitomycin C", International Journal of Pharmaceutics, 22:75-87, (1984)
  • van Heeswijk, et al., "The Synthesis and Characterization of Polypeptide . . . with Adriamycin. Part 1", Journal of Controlled Release, 1:301-315, (1985)
  • Anderson, "In Vitro and In Vivo Studies of Drug-Releasing Poly(amino acids)," Annals New York Academy of Sciences, 67-75 (1985)
  • Borbely et al., "Biosynthesis and Chemical Modification of Poly( -glutamic acid)," Polymer Bulletin 32, 127-132 (1994)
  • Goodman et al., "Immunochemical Studies on the Poly--D-glutamyl Capsule of Bacillus Anthracis. I. Characterization of the Polypeptide and of the Specificity of Its Reaction With Rabbit Antisera," Biochemistry 5, No. 2 657-664 (1966)
  • Goodman et al., "Immunochemical Studies on the Poly--D-glutamyl Capsule of Bacillus Anthracis. III. The Activity with Rabbit Antisera of Peptides Derived from the Homologous Polypeptide," Biochemistry 7, No. 2 706-710 (1968)
  • Jensen et al., "Production of Recombinant Human Growth Hormone in Escherichia coli: Expression of Different Precursors and Physiological Effects of Glucose, Acetate, and Salts," Biotechnology and Bioengineering, 36 1-11 (1990)
  • Nitecki et al., "Immunochemical Studies on the Poly( -glutamyl Capsule of Bacillus anthracis. II. The Synthesis of Eight Dipeptides and Four Tripeptides of Glutamic Acid," Biochemistry 5, 665-672 (1966)
  • Shah et al., "New Polymers Derived From Natural Origin -Poly(Glutamic Acid)," Polymer Preprints, 33 No. 2 488-490 (1992)
  • Thorne et al., "Production of Glutamyl Polypeptide By Bacillus Subtilis," Journal of Bacteriology, 68 307-315 (1954)
  • Tsukada et al., "An Anti-଱-Fetoprotein Antibody-Daunorubicin Conjugate With A Novel Poly-L-glutamic Acid Derivative as Intermediate Drug Carrier," JNCI, 73, No. 3 721-729 (1984
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
PatentsPlus: add to cart
PatentsPlus: add to cartIntelligent turbocharged patent PDFs with marked up images
$16.95more info
 
Sign InRegister
Username  
Password   
forgot password?