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US Patent 5897858 - Nasal spray compositions exhibiting increased retention in the nasal cavity
US Patent Issued on April 27, 1999
Estimated Patent Expiration Date:
November 4, 2017Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
November 4, 2017Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractAqueous nasal spray compositions containing:0.001-2% by weight/volume of a medicament selected from the group consisting of chlorpheniramine maleate, oxymetazoline hydrochloride and mixtures thereof;0.50 to 15.00% by weight/volume of a water soluble polymer selected from the group consisting of polyvinylpyrrolidone having an average molecular weight of about 10,000 to 360,000 and mixtures thereof;2.5 to 10.00% by weight/volume of polyethylene glycol;1.00 to 10.00% by weight/volume of a moisturizing agent other than polyethylene glycol;0.01 to 0.05% by weight/volume of disodium edetate;0.001 to 0.3% by weight/volume of an antimicrobial preservative;0.20 to 5.00% by weight/volume of an aromatic alcohol;a sufficient amount of a pharmaceutically acceptable buffer to maintain the pH of the composition within the range of about 4.0 to 8.0; andQS water.Other References
| InventorsAssigneeApplicationNo. 964038 filed on 11/04/1997US Classes:424/78.04, Ophthalmic preparation424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)424/434, Mucosal (e.g., nasal, etc.)424/601, Phosphorus or phosphorus compound514/772.5, Heterocyclic monomer514/853, DECONGESTANT514/912, OPHTHALMIC514/937DISPERSION OR EMULSIONField of Search424/45, Organic pressurized fluid424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)424/601, Phosphorus or phosphorus compound424/434, Mucosal (e.g., nasal, etc.)424/78.04, Ophthalmic preparation514/772.5, Heterocyclic monomer514/937, DISPERSION OR EMULSION514/912, OPHTHALMIC514/853DECONGESTANTExaminersPrimary: Bawa, RajAttorney, Agent or FirmUS Patent References4581225, Sustained release intranasal formulation and method of use thereofIssued on: 04/08/1986 Inventor: Su , et al.5114979, Fruity flavored nasal decongestant composition Issued on: 05/19/1992 Inventor: Kielley 5116847 Foreign Patent References
International ClassA61K 009/08 |
