Nasal spray compositions exhibiting increased retention in the nasal cavity
Patent 5897858 Issued on April 27, 1999. Estimated Expiration Date: 
November 4, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 4, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSustained release intranasal formulation and method of use thereof Fruity flavored nasal decongestant composition 5116847 InventorsAssigneeApplicationNo. 964038 filed on 11/04/1997US Classes:424/78.04, Ophthalmic preparation424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)424/434, Mucosal (e.g., nasal, etc.)424/601, Phosphorus or phosphorus compound514/772.5, Heterocyclic monomer514/853, DECONGESTANT514/912, OPHTHALMIC514/937DISPERSION OR EMULSIONExaminersPrimary: Bawa, RajAttorney, Agent or FirmForeign Patent References
International ClassA61K 009/08AbstractAqueous nasal spray compositions containing:0.001-2% by weight/volume of a medicament selected from the group consisting of chlorpheniramine maleate, oxymetazoline hydrochloride and mixtures thereof;0.50 to 15.00% by weight/volume of a water soluble polymer selected from the group consisting of polyvinylpyrrolidone having an average molecular weight of about 10,000 to 360,000 and mixtures thereof;2.5 to 10.00% by weight/volume of polyethylene glycol;1.00 to 10.00% by weight/volume of a moisturizing agent other than polyethylene glycol;0.01 to 0.05% by weight/volume of disodium edetate;0.001 to 0.3% by weight/volume of an antimicrobial preservative;0.20 to 5.00% by weight/volume of an aromatic alcohol;a sufficient amount of a pharmaceutically acceptable buffer to maintain the pH of the composition within the range of about 4.0 to 8.0; andQS water.Other References
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