Patent 5895787 Issued on April 20, 1999. Estimated Expiration Date: October 8, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A method of treating fibromyalgia-like complaints (i.e., fibromyalgia, chronic fatigue syndrome and irritable bowel syndrome) in a patient, the method comprising: administering to the patient an 1H-indole-3-methanol compound (e.g., 1H-indole-3-methanol, ascorbigen, bis(3-indolyl) methane, indolo3,2-b(carbazole)!, 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, 5,6,11,12,17,18-hexahydrocyclonona, 1,2-b;4,5-b';7,8-b"!triindole, 1H-indol-3-yl methoxy methane, ethoxy 1H-indol-3-yl ethoxy methane, other ethers of 1H-indole-3-methanol) in a medically acceptable manner in a pharmaceutically effective amount on a regular basis. It has been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly mitigates the most severe symptoms of fibromyalgia. Patients with fibromyalgia have reported a decrease in pain, less fatigue, improved sleep patterns, and an improved sense of well being resulting from the oral administration of pharmaceutically effective amounts of an 1H-indole-3-methanol compound each day.
Other References
Bennett, Robert, "Fibromyalgia and the Disability Dilemma", Arthritis & Rheumatism, vol. 39, No. 10, pp. 1627-1634, Oct. 1996
Carette, Simon, "Fibromyalgia 20 years later: What Have We Really Accomplished?", The Journal of Rheumatology, 22:4, pp. 590-594, 1995
Designed Nutritional Products, "Product Information", 1 sheet, Mar. 1, 1997
Hadler, Nortin M., "If You Have to Prove You Are Ill, You Can't Get Well", Spine, vol. 21, No. 20, pp. 2397-2400, 1996
Life Plus Foundation, "Relief From Chronic Fatigue Syndrome", Internet web site information, 7 pages, Jul. 9, 1997
Michnovicz et al., "Changes in Levels of Urinary Estrogen Metabolites After Oral Indole-3-Carbinol Treatment in Humans", Journal of the National Cancer Institute, vol. 89, No. 10, pp. 718-723, May 21, 1997
Michnovicz et al., "Dietary Cytochrome P-450 Modifiers in the Control of Estrogen Metabolism", Food Phytochemicals I: Fruits and Vegetables, pp. 282-293
Nye, David A., "Fibromyaigia -- a guide for patients", Sapient Health Network, 7 pages, Aug. 13, 1995
Nye, David A., "Fibromyaigia -- A Physician's Guide", Sapient Health Network, 9 pages, 1995
Physical Medicine Research Foundation, "The Fibromyalgia Syndrome: A Consensus Report on Fibromyalgia and Disability", The Journal of Rheumatology, 23:3, pp. 534-539, 1996
Romano et al., "Fibromyalgia 20 Years Later: What We Really Accomplished?", The Journal of Rheumatology, 23:1, pp. 192-194, 1996
Thrive @ the healthy living experience, "Chronic Pain", 6 pages, 1996
Wolfe et al., "Aspects of Fibromyalgia in the General Population: Sex, Pain Threshold, and Fibromyalgia Symptoms", The Journal of Rheumatology, 22:1, pp. 151-156, 1995
Wolfe, Frederick, "Fibrositis, Fibromyalgia, and Musculoskeletal Disease: The Current Status of the Fibrositis Syndrome", Arch Phys Med Rehabil, vol. 69, pp. 527-531, Jul. 1988
Wolfe et al., "The Prevalence and Characteristics of Fibromyalgia in the General Population", Arthritis & Rheumatism, vol. 38, No. 1, pp. 19-28, Jan. 1995
Wolfe, Frederick, "When To Diagnose Fibromyalgia", Diagnostic Issues, vol. 20, No. 2, pp. 485-501, May 199