Abstract Claims Description Full Text

Abstract

Treatment of Parkinson's disease, parkinsonian syndromes, extrapyramidal syndromes, obsessive-compulsive disorder and syndromes, and frontal and subcortical dementias, with imidazo›1,2-a!pyridine-3-acetamide derivatives of the formula (I) ##STR1## wherein Y represents a hydrogen or halogen atom or a C1-4 alkyl group, A represents naphthyl or C6 H3 X1 X2, wherein each of X1 and X2 independently of one another is a hydrogen or halogen atom, a C1-4 alkoxy group, a C1-6 alkyl group or CF3, CH3 S-- , CH3 SO2 -- or --NO2, and each of R1 and R2 independently of one another represents either a hydrogen atom, or a straight or branched C1-5 alkyl group which is unsubstituted or substituted by one or more halogen atoms, hydroxyl, --N(C1-4 alkyl)2, carbamoyl or C1-4 alkoxy groups, or an allyl group, or a propargyl group, or a C3-6 cycloalkyl group, or a benzyl group, or a phenyl group, not both R1 and R2 being hydrogen, or --NR1 R2 represents a heterocyclic ring containing from 3 to 6 carbon atoms, or a heterocyclic ring of the formula ##STR2## wherein X is O, S, CHOR' or N--R, R' being hydrogen or benzyl and R being hydrogen, a C1-4 alkyl group, or phenyl which is unsubstituted or substituted by methoxy or a halogen atom, provided that if Y is 6-chloro, A is not 4-chlorophenyl.

Other References

• Annals of Neurology, vol. 39, No. 3, Mar. 1996, pp. 368-377, XP002008555, K.G. Rottach et al, "Dynamic Properties of Horizontal and Vertical Eye Movements in Parkinsonian Syndromes"
• ACTA Psychiatr. Scand., vol. 80, No. 2, Aug. 1989, pp. 137-141, XP002008556, M. Casacchia et al, "A double-blind, placebo-controlled study of alpidem, a novel anxiolytic of imidazopyridine structure. . . "
• Database Embase, Elsevier Science Publishers, Amsterdam, NL, Accession No. 92058496, 1992, Abou-Gharbia et al, XP002008559, "IV Congress of the ECNP"; Drug News Perspect., vol. 4, No. 10, 1991, pp. 647-650
• Am. Pharm., vol. 34, No. 3, Mar. 1994, pp. 24-59, XP002008557, D.A. Hussar, "New Drugs of 1993"
• Sem. Hop., vol. 67, No. 42-43, 1991, pp. 1905-1908, XP002008558, D. Ginestet et al, "Anxiete et insomnie: Quelles alternatives medicamenteuses aux benzodiazepines?