Use of imidazo 1, 2-A! pyridine-3-acetamide derivatives for the therapeutic treatment of neuropsychiatric syndromes associated with disfunction of the neural circuits of the basal ganglia
Patent 5891891 Issued on April 6, 1999. Estimated Expiration Date: 
November 18, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 18, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod of stimulating steroidogenesis with alpidem Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders Patent #: 5206382 InventorAssigneeApplicationNo. 930644 filed on 11/18/1997US Classes:514/300Plural hetero atoms in the bicyclo ring systemExaminersPrimary: Spivack, Phyllis G.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/44A61K 031/415 Foreign Application Priority Data1996-04-07 ITAbstractTreatment of Parkinson's disease, parkinsonian syndromes, extrapyramidal syndromes, obsessive-compulsive disorder and syndromes, and frontal and subcortical dementias, with imidazo1,2-a!pyridine-3-acetamide derivatives of the formula (I) ##STR1## wherein Y represents a hydrogen or halogen atom or a C1-4 alkyl group, A represents naphthyl or C6 H3 X1 X2, wherein each of X1 and X2 independently of one another is a hydrogen or halogen atom, a C1-4 alkoxy group, a C1-6 alkyl group or CF3, CH3 S-- , CH3 SO2 -- or --NO2, and each of R1 and R2 independently of one another represents either a hydrogen atom, or a straight or branched C1-5 alkyl group which is unsubstituted or substituted by one or more halogen atoms, hydroxyl, --N(C1-4 alkyl)2, carbamoyl or C1-4 alkoxy groups, or an allyl group, or a propargyl group, or a C3-6 cycloalkyl group, or a benzyl group, or a phenyl group, not both R1 and R2 being hydrogen, or --NR1 R2 represents a heterocyclic ring containing from 3 to 6 carbon atoms, or a heterocyclic ring of the formula ##STR2## wherein X is O, S, CHOR' or N--R, R' being hydrogen or benzyl and R being hydrogen, a C1-4 alkyl group, or phenyl which is unsubstituted or substituted by methoxy or a halogen atom, provided that if Y is 6-chloro, A is not 4-chlorophenyl.Other References
Field of SearchPlural hetero atoms in the bicyclo ring system | |
