U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Creatine pyruvate salt with enhanced palatability

Patent 5886040 Issued on March 23, 1999. Estimated Expiration Date: Icon_subject June 17, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventor

Assignee

Application

No. 877612 filed on 06/17/1997

US Classes:

514/557, Carboxylic acid, percarboxylic acid, or salt thereof (e.g., peracetic acid, etc.)514/634Guanidines (i.e., N=C(-N)-N)

Examiners

Primary: Weddington, Kevin E.

Attorney, Agent or Firm

International Classes

A61K 031/19
A61K 031/155

Abstract

An organic salt formed between creatine and pyruvic acid and their attendant salts and analogs, is water soluble and possesses improved palatability. The creatine is in a chemical form which increases its resistance to aqueous acid hydrolysis. The creatine cation provides the additional energy which the demands of a pyruvate induced metabolic state require. The result is a salt, which, when ingested results in increased energy and an enhanced metabolic rate.

Other References

  • Cannan, Shore, CXV. The Creatine-Creatinine Equilibrium. The Apparent Dissociation Constants of Creatine and Creatinine, 22 Biochem. J. 924, 1928
  • Hultman E. et al., Energy metabolism and fatigue. 73-92
  • Cortez et al., Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats, 53 American Journal of Clinical Nutrition 847-853, 1991
  • Greenhaff et al., Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man, 84 Clinical Science 565-571, 1993
  • Harris et al., Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation, 83 Clin. Sci. 367-74, 1992
  • Walker J.B. Creatine: Biosynthesis, regulation, and function, 50 Adv. Enzymology and Related Areas of Molecular Biology 177-242, 1979
  • Stanko et al., Enhancement of arm exercise endurance capacity with dihydroxyacetone and pyruvate, 68 Journal of Applied Physiology 119-124, 1990
  • Stanko et al., Enhanced leg-exercise endurance with a high-carbohydrate diet and dihydroxyacetone and pyruvate, 69 Journal of Applied Physiology 1651-1656, 1990
  • Stanko et al., Body composition and Energy Utilization and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplement with pyruvate, 56 American Journal of Clinical Nutrition 630-635, 1992
  • Stanko et al., Inhibition of lipid accumulation and enhancement of energy expenditure by the Addition of Pyruvate and Dihrdyoxyacetone consumption on the growth and metabolic State of Zucker Rats, 35 Metabolism 182-286, 1986
  • Stanko et al., Inhibition of lipid accumulation and enhancement of energy expenditure by addition of pyruvate and dihydroxyacetone to a rat diet, 35 Metabolism 182-186, 198
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